Research Article Factors Associated with the Prevalence of Hepatitis B among Volunteer Blood Donors at Jimma Blood Bank, South Ethiopia Hamba Yigezu, 1 Juhar Temam, 2 Mitiku Bajiro, 3 Leta Tesfaye Jule , 4,5 N. Nagaprasad , 6 Arpita Roy , 7 Abel Saka , 4 and Krishnaraj Ramaswamy 5,8 1 Department of Public Health, College of Medicine and Health Science, Dambi Dollo University, Dembidolo, Ethiopia 2 School of Medical Laboratory, Institute of Health Science, Jimma University, Jimma, Ethiopia 3 Department of Medical Parasitology, Public Health Department, Dambi Dollo University, Dembidolo, Ethiopia 4 Department of Physics, College of Natural and Computational Science, Dambi Dollo University, Dembidolo, Ethiopia 5 Centre for Excellence-Indigenous Knowledge, Innovative Technology Transfer and Entrepreneurship, Dambi Dollo University, Dembidolo, Ethiopia 6 Department of Mechanical Engineering, ULTRA College of Engineering and Technology, Madurai 625104, Tamilnadu, India 7 Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida 201310, India 8 Department of Mechanical Engineering, College of Engineering and Technology, Dambi Dollo University, Dembidolo, Ethiopia Correspondence should be addressed to Krishnaraj Ramaswamy; prof.dr.krishnaraj@dadu.edu.et Received 7 September 2021; Revised 2 February 2022; Accepted 6 May 2022; Published 23 May 2022 Academic Editor: Yu-Chen Fan Copyright © 2022 Hamba Yigezu et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Hepatitis B is a severe, widespread infectious disease of the liver that affects millions of people around the world. It is one of the life-threatening liver infections caused by the hepatitis B virus (HBV). HBV is the cause of up to 80% of cases of primary liver cancer. Due to the potential risk associated with HBV infection, it is important to study the factors which are associated with the seropositive volunteers. Objective. e purpose of this study was to identify factors associated with seropositivity for the hepatitis B virus among volunteers who donated blood at the Jimma Blood Bank in southern Ethiopia. Methods. Cross-sectional research was conducted on blood donors who came to the Jimma Blood Bank to donate their blood. ree hundred and fifty-nine volunteer blood donors who arrived at the Jimma Blood Bank were investigated face-to-face in order to collect sociodemographic characteristics and risk factors for HBV infection. e data were analyzed using statistical software SPSS version 20.0. e association between the risk factor for HBV infection and HBV infection was determined using chi-square tests. Result. In total, there were 359 participants; their mean age was 22.5, among which 161 (44.8%) were males. Out of 359 volunteers, 13 (3.6%) were seropositive for HBsAg. e test positivity rate among males was 7/198 (3.54%), while the rate among females was 6/161 (3.7%). More than 3/4 of those who tested positive were under the age of 40. Chi-square analysis showed that volunteers whose income was between 12 and 26.84 USD were less likely to have the infectious disease than those whose income was less than 11.84 USD per month (p  0.042). Conclusion. e prevalence of HBV was found to be 3.6% among selected volunteers. It was found that, out of 20 volunteers, 13 had infection. Chi-square analysis showed that HBV infection was associated with low monthly income and the use of unsafe therapeutic injections. 1. Introduction HBV is a well-known hepadnavirus with a double-stranded circular DNA genome [1]. A total of ten HBV genotypes (HBV-A through J) have been identified, with a wide geo- graphic distribution, and their entire genomic sequences vary by an average of over 8%, which is important [2]. Each year, millions of people are affected by viral hepatitis, which causes disability and death in a number of countries around the world. HBV and HCV are chronically diseased in ap- proximately 500,000,000 people worldwide [1]. e causes of viral hepatitis include primarily liver disease, which includes liver cancer, and more than 200,000 people die each year (about 2.7% of all deaths) from these causes [3]. According Hindawi Canadian Journal of Gastroenterology and Hepatology Volume 2022, Article ID 7458747, 5 pages https://doi.org/10.1155/2022/7458747