S1 Supporting information (SI) Plant Response to Metal-Containing Engineered Nanomaterials: An Omics- Based Perspective Roberta Ruotolo, Elena Maestri, Luca Pagano, Marta Marmiroli, Jason C. White and Nelson Marmiroli Contents Additional details on negative and positive effects of metal-based ENMs in plants. Figure S1. Box plot of log 2 -transformed gene expression data. Figure S2. Hierarchical clustering of TiO 2 NP-responsive genes in A. thaliana. Figure S3. Metabolic pathways associated with the transcriptional changes induced by the exposure of A. thaliana to ZnO NPs. Number of pages of the Supporting information: 10 Number of figures: 3