JPET #55798 Six novel non-synonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes Norie Murayama, Akiko Soyama, Yoshiro Saito, Yukiko Nakajima, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Hideo Kimura, Yu-ichi Goto, Osamu Saitoh, Masaaki Katoh, Teiichi Ohnuma, Mitsuru Kawai, Kenji Sugai, Taisuke Ohtsuki, Chieko Suzuki, Narihiro Minami, Shogo Ozawa and Jun-ichi Sawada Project team for Pharmacogenetics (N.M., A.K., Y.S., Y.N., S.O., J.S.), Division of Biochemistry and Immunochemistry (Y.S., J.S.), Division of Pharmacology (S.O.), National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan, Department of Cardiology (K.K., S.K., M.K.), Department of Cardiovascular Dynamics Research Institute (K.K.), Department of Pharmacy (K.U.), National Cardiovascular Center, Osaka 565-8565, Japan, 3 National Institute of Neuroscience (H.K., Y.G., N.Mi.), 4 National Center Hospital for Mental Nervous and Muscular Disorders (O.S., M.K., T.O., M.K., K.S., Ta,O., C.S., N.Mi.), National Center for Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan Copyright 2003 by the American Society for Pharmacology and Experimental Therapeutics. JPET Fast Forward. Published on October 16, 2003 as DOI:10.1124/jpet.103.055798 This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on October 16, 2003 as DOI: 10.1124/jpet.103.055798 at ASPET Journals on January 13, 2022 jpet.aspetjournals.org Downloaded from