J Food Sci Nutr Res 2020; 3 (2): 102-120 DOI: 10.26502/jfsnr.2642-11000042 Journal of Food Science and Nutrition Research 102 Research Article Nutritional Composition, Glycaemic Properties and Anti-Diabetic Potentials of Cereal-Based Soy-Fortified Flours for Functional Dough Meal in Diabetic Induced Rats Akinjayeju O * , Ijarotimi OS, Awolu OO, Fagbemi TN Department of Food Science and Technology, Federal University of Technology, Akure, Nigeria * Corresponding Author: Oluwole Akinjayeju, Department of Food Technology, Yaba College of Technology, P.M.B.2011, Yaba-Lagos, Nigeria, Tel: +234-8055007234; E-mail: olujayeju2@gmail.com Received: 24 March 2020; Accepted: 06 April 2020; Published: 24 April 2020 Citation: Akinjayeju O, Ijarotimi OS, Awolu OO, Fagbemi TN. Nutritional Composition, Glycaemic Properties and Anti-Diabetic Potentials of Cereal-Based Soy-Fortified Flours for Functional Dough Meal in Diabetic Induced Rats. Journal of Food Science and Nutrition Research 3 (2020): 102-120. Abstract This study evaluated glycaemic properties and anti- diabetic potentials of blends of quality-protein-maize (QPM), soy-cake (DSF), millet (WMF) flours for functional dough meal using cassava starch (CST) as binder. Protein and crude fibre contents of blends were optimized using RSM and three blends with highest protein and fibre contents, XYZ=76.03% QPM, 16.76% DSF, 7.21% WMF, 5.00% cassava starch; BCD=72.50% QPM, 2.50% WMF, 25.0% DSF, 2.33% CST; FDT=80.52% QPM, 3.06% WMF, 16.42% DSF, 5.00%), QPM (100% QPM flour) and CER (commercial anti-diabetic flour formulation) were evaluated for glycaemic and biochemical properties and blood glucose-reducing potentials using Wistar rats. Glycaemic index and load were 34-52% and 8-15% respectively, which were lower than 55% and 20% for low glycaemic index and load. Blood glucose-reducing potentials of samples were in ascending order of BCD (57.5%) < FDT (70%) < XYZ (75%), with samples FDT and XYZ higher than 62.5% for sample STD (rats treated with synthetic anti-diabetic agent- Glibenclamide). Haematological indices, PVC, Hb, WBC and RBC, of rats fed on samples were 46.35- 51.25%, 13.40-18.10g/L, 8.30-10.80 (x10/mm 3 ) and 4.19-6.94 (x10 6 ) respectively, while kidney and liver functionality indices, aspartate amino transferases (AST), alanine amino transferases (ALT) and alkaline phosphate (ALP) were 39.5-43.00 μ/L, 48.50-55.50 μ/L and 92.80-104.20 μ/L, within normal ranges of 7-56μ/L, 45.7-80.8μ/L and 41-133 U/L, respectively.