Jasna Prodanović-Radulović, et. al. Contemporary Agriculture, 64 (1-2)105-111, 2015. 105 The Serbian Journal of Agricultural Sciences Srpski časopis za poljoprivredne nauke Vol. 64, No. 1 - 2, Pp. 1 - 119, 2015. www:Contemporary Agriculture ISSN: 0350-1205 UDC: 63(497.1)(051)-“540.2” University of Novi Sad, Serbia Published by Faculty of Agriculture, Novi Sad Review paper UDC: 636.09:578.819 EMERGENCE OF PSEUDORABIES VIRUS (MORBUS AUJESZKY) INFECTION AT LARGE SWINE FARMS IN AP VOJVODINA (SERBIA) * Jasna PRODANOV-RADULOVIĆ ♦ , Radoslav DOŠEN, Ivan PUŠIĆ, Tamaš PETROVIĆ, Jelena APIĆ, Igor STOJANOV, Vladimir POLAČEK 1 Summary: The aim of this paper was to evaluate current epidemiological situation concerning occurrence of Aujeszky′s disease (AD) outbreak in large swine farms in Vojvodina Province. The material for this research included the samples from five swine farms, where certain disorders and health problems in suckling pigletsi.e. clinical signs suggesting AD were detected. Depending on the specificity of each evaluated case and available material, the applied research methods included: epidemiological and anamnestical evaluation, clinical investigation, gross pathological examination, standard bacteriological examination for detection the presence of aerobic and anaerobic bacteria in the organs and tissue samples (lungs, tonsils, lympho nodes, spleen, cerebral tissue) derived from diseased, died pigs.Viral isolation on the susceptible cell culture and molecular diagnostic method (RT-PCR) were applied.Also, the material for the investigation included 300 blood samples collected from breeding animals, in order to evaluate the presence of specific antibodies against AD virus. The achieved results suggest that swine population in AP Vojvodina province is enzootically infected with AD virus. Besides vaccination, which represents one of the measure in AD eradication, it is necessary to apply strict trade control and checking the health status of herds from where breeding animals are purchased. Key words: Aujeszky′s disease, Pseudorabies, swine farms, Vojvodina. INTRODUCTION Aujeszky′s disease (Pseudorabies, Morbus Aujeszky) is an acute, contagious viral disease, of wide range of domestic and wild-life species (Allepuz et al., 2009). The causative agent is designated as suis alpha herpes virus 1, a member of the Herpes viridae family and Alphaherpes virinae subfamily (Mettenleiter et al., 2012). The Aujeszky′s diseasevirus (ADV) is an important pathogen of pigs and infects almost all mammalian species exept man. However, 1 Jasna Prodanov-Radulović, DVM, MSc, PhD, Research Associate, Radoslav Došen, MSc, PhD, Advisor specialist, Tamaš Petrović, DVM, MSc, PhD, Senior Research Associate, Jelena Apić, DVM, MSc, Research Assistant, Igor Stojanov, DVM, MSc, PhD, Senior Research Associate, Vladimir Polaček, DVM, MSc, PhD, Research Associate, Scientific Veterinary Institute „Novi Sad“, Rumenački put 20, 21000 Novi Sad, Serbia. ♦ Corresponding author: Jasna Prodanov-Radulović, e-mail: jasna.prodanov@gmail.com, Tel.: +381 21 4895-314. *This paper is a result of the research within the project TR31084 financed by the Ministry of Education, Science and Technological Development, Republic of Serbia, 2011-2015.