ew Journal of Drug Design and Development Open Access | Page 44 | Vol 2 | Issue 1 | Pages 44-48 Copyright: © 2021 Etu SF, et al. This is an open-access artcle distributed under the terms of the Creatve Commons Atributon License, which permits unrestricted use, distributon, and reproducton in any medium, provided the original author and source are credited. DOI: 10.36959/426/606 SCHOLARS. DIRECT *Corresponding author: Nazmul Qais, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh, Tel: +880-1714417750 Accepted: October 29, 2021 Published online: October 31, 2021 Citaton: Etu SF, Alqahtani A, Qais N (2021) 5,10-Dihydro-7,8-Di- methyl Alloxazine as an Antcancer Agent from Lumichrome of Ribofavin. J Drug Des Devel 2(1):44-48 5,10-Dihydro-7,8-Dimethyl Alloxazine as an Anticancer Agent from Lumichrome of Ribofavin Shafa Farhana Etu 1 , Ali Alqahtani 2 and Nazmul Qais 1* 1 Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh 2 Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha, Saudi Arabia Research Article Introduction Cancer is stll considered as one of the most dreaded diseases in the world. In 2020, an estmated 19.3 million new cancer patents were reported by the Internatonal Agency for Research on Cancer (IARC). It is predicted that this number of cancer patents will rise up to 28.4 million in the next two decades, mostly from developing countries [1]. Breast cancer, liver cancer and colorectal cancer are some commonly occurring cancers. Of almost 9.9 million cancer Abstract Scientsts are contnuing their relentless endeavor to fnd a remedy for cancer or therapeutc agents which will minimize the growing burden of this seemingly incurable disease to a great extent. From literature review, we got the insight that a photoproduct of ribofavin named lumichrome has antcancer efect against lung cancer and this demands working on this compound and evaluaton of antcancer actvity. The present study represents the potental antcancer property of lumichrome and its synthesized derivatve 5,10-dihydro-7,8-dimethyl alloxazine against liver, breast and colorectal cancer. Cytotoxic actvity was investgated by in vitro sulforhodamine B (SRB) assay against HepG2 (Hepatocellular car- cinoma), MCF-7 (Breast Adenocarcinoma), Colo-205 (Colorectal cancer) cell lines. IC 50 values were between 7.7 to 23.9 μg/ml. HepG2 cell line was most sensitve to lumichrome as well as its synthesized derivatve with IC 50 values of 7.7 and 17.2 μg/ml respectvely. The mechanisms of actons of these compounds are thought to involve inducton of apoptosis and interference with the transcripton process. Future studies will be required to confrm their mechanism of actons (Graphical Abstract). Keywords Antcancer, Lumichrome, 5,10-dihydro-7,8-dimethyl alloxazine, Breast cancer, Liver cancer, Colorectal cancer Check for updates