International Journal of Science and Research (IJSR) ISSN: 2319-7064 ResearchGate Impact Factor (2018): 0.28 | SJIF (2018): 7.426 Volume 9 Issue 1, January 2020 www.ijsr.net Licensed Under Creative Commons Attribution CC BY Correlation between Swelling Post Odontectomy in Lower Third Molar with the Increase of Concentration Alpha Amylase Saliva Idawati Muhajir 1 , Harmas Yazid Yusuf 2 , Lucky Riawan 3 1, 2, 3 Oral and Maxillofacialial Surgery Departement, Faculty of Dentistry, Universitas Padjadjaran,Bandung, Indonesia Abstract: Introduction : Odontectomy is surgical procedure that cause inflammation involving post-operative pain, swelling, and general oral dysfunction during the immediate post-operative phase. There are several methods for identify swelling post odontectomy, such measurement of compositions concentration saliva. Alpha amylase is one of the composition of saliva that considered to have a correlation with post odontectomy swelling. Objective : This study aimed to investigate the correlation between the swelling post odontectomy in lower third molar with the concentration level of alphaamylase. Method : A consecutive random sampling study involving was performed in 41 patients. Patience were categorized into classification of impacted teeth (class Ia, Ib, Ic, IIa, IIb, IIc). The measurement of facial dimension was performed in preoperative, post-operative day 1, post-operative day 3, post-operative day 7, and the measurement of concentration alphaamylase level was performed in preoperative, post-operative 2 hourss, post-operative day 3, post- operative day 7. Result : The results of the study, there was no significant relationship between swelling post odontectomy in lower third molar with increased of concentration alphaamylase of class impaction Ia (r=0,96;p value > 0,05), Ib (r= -0,60;p value > 0,05),Ic (r=0,79;p value> 0,05), and significant relationship of class impaction IIa (r=-0,66;p value < 0,05), IIb (r=-0,82;p value < 0,05), IIc (r=- 0,19;p value < 0,05) for each variabel. Conclusion : In conclusion, there were no significant relationship between swelling post odontectomy in lower third molar with increased of concentration alphaamylase of class impaction Ia, Ib, Ic and significant relationship of class impaction IIa,IIb,IIc. Keywords: Odontectomy, Swelling, AlphaAmylase 1. Introduction Odontectomy is one of the most common dentoalveolar procedure. Odontectomy is the procedure to remove the impacted tooth that has been done with removing a tooth into few pieces without excessive cutting of alveolar bone. Complications of the odontectomy are swelling, pain, infection, dry socket, trismus, etc. Swelling cause the change of facial dimension and buccal thickness at odontectomy area. Swelling will last for 3 for 4 days and will subside within 5 for 7 days and it can cause the difficulty on the move, normally it will last for the first 3 days post odontectomy. 1–3 Few factors that influence the complication post odontectomy are ages, smoking habit, oral hygiene instruction, type of impaction, thickness of alveolar bone, duration of operation, operation technique, complication during operation and experience of surgeon. Impacted of lower third molar need the minimal tissue incision, however, the consequence of swelling post odontectomy is the unavoidable, especially if we remember that this procedure will lead to soft tissue trauma that release inflammatory mediator from mast cell, and other cells such as histamine, serotonin, bradikinin and prostaglandin that have a role in inflammation process. Inflammation can cause the swelling that lead to infection, trismus and asymmetrical face and pain. 2,4,5,8 To identify the swelling post operation, most of them can be evaluated through the clinical examination. Therefore, in little research, the swelling can be identified with the use of different diagnostic criteria such as objective and non- invasive procedure to evaluate the inflammation, like measuring the concentration composition of saliva that form biology fluid which important to diagnose the oral diseases. This fluid becomes the alternative from blood, serum or plasma and contain of variant protein, hormone, antibody, sitokinin which enter the saliva through the blood, therefore the most component that exist in blood also exist in saliva. 4,6,7 One of the biomarkers saliva that is related to the swelling post odontectomy of lower third molar is alphaamylase that can be obtained from secretion of saliva under the autonomic nerve. Alphaamylase saliva is the indicator to show the autonomic activity from salivary gland. Secretion of alphaamylase in human is the response to the neurotransmitter stimulus and controlled by nerve of sympathetic and parasympathetic from mouth. Alphaamylase enzyme is the enzyme that exist in saliva and becoming one of the indicators of inflammatory process. The increase of concentration of alphaamylase saliva in post operation lower third molar, related to inflammation process to operation. 4 According to the things above, the researcher interest to investigate the correlation of swelling post odontectomy lower third molar with the increase of alphaamylase concentration in patient that will be perform odontectomy in Dental Hospital University of Padjadjaran Bandung. 2. Material &Methods This research conducted in 41 research subjects with the age range 19-45 years old that undergone odontectomy of lower wisdom tooth in Unpad Dental Hospital Bandung. Paper ID: ART20204121 DOI: 10.21275/ART20204121 870