Journal of Perinatology https://doi.org/10.1038/s41372-019-0325-x JOURNAL CLUB Should we target higher or lower oxygen saturation targets in the preterm infant? Sarah Drennan 1 ● Edgardo Szyld 1 Received: 26 December 2018 / Accepted: 7 January 2019 © Springer Nature America, Inc. 2019 Manuscript citation: Askie LM, Darlow BA, Finer N, Schmidt B, Stenson B, Tarnow-Mordi W, et al. Association between oxygen saturation targeting and death or disability in extremely preterm infants in the neonatal oxygenation prospective meta-analysis collaboration. JAMA 2018;319:2190–201. Type of investigation Prognosis Question In infants born before 28 weeks gestation, do lower oxygen saturation targets (85–89%) versus higher oxygen saturation targets (91–95%) affect death or major disability at a cor- rected age of 18–24 months? Methods Design Prospectively designed, multi-national, multi-center, meta- analysis of five prospective randomized control trials Blinding Intervention groups were blinded to parents, caregivers, and outcome assessors by using a modified pulse oximeter, adjusted to display saturations 88–92% ± 3%. True values were only displayed if actual SpO 2 < 84% or >96%. Patients Infants born before 28 weeks’ gestation and enrolled within 24 h of life were included. Intervention Subjects were randomized to receive supplemental oxygen to maintain oxygen saturations via pulse oximeter in the range of 85–89% in one group compared to 91–95% in the second group while in the NICU. Intervention was con- tinued until 36 weeks post-menstrual age with slight var- iations per study. Outcomes Primary composite of death or major disability at a corrected age of 18–24 months (major disability defined as any of the following: Bayley-III cognitive or language score < 85, severe visual loss defined as cannot fixate or legally blind with visual acuity < 6/60 in both eyes, CP with GMFCS level 2 or higher, or deafness requiring hearing aids). Secondary Total of 16 secondary outcomes including the components of the primary outcome and other major morbidities were studied. * Sarah Drennan sarah-drennan@ouhsc.edu 1 Department of Pediatrics Division of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center at Oklahoma City, PO Box 269011200 Everett Drive, 7th Floor North Pavilion, Oklahoma, OK 73104, USA 1234567890();,: 1234567890();,: