Mediterr J Hematol Infect Dis 2013; 5; Open Journal Syste MEDITERRANEAN JOU Case Report Primary Pulmonary Hodgkin Uncommon Occurrence Stefano Fratoni 1 , Elisabetta Abruzzese 2 , P Andrea Casullo 4 , Paolo de Fabritiis 2 , Ales 1 Pathology Department, S. Eugenio Hospit 2 Hematology Department, S. Eugenio Hos 3 Department of Thoracic Surgery, S. Euge 4 Department of Radiology, S. Eugenio Hos Correspondence to: Pasquale Niscola, He 00144 - Rome, Italy. Tel: +390651002390 Competing interests: The authors have de Published: February 16, 2013 Received: November 16, 2012 Accepted: January 6, 2013 Citation: Mediterr J Hematol Infect Dis 2013, 5 This article is available from: http://www.mjhi This is an Open Access article distrib (http://creativecommons.org/licenses/by/2.0 ), w provided the original work is properly cited. Abstract. The case of a patient w mediastinal tumour is reported for it Introduction. Although the secondary i lung parenchyma by Hodgkin's lymphom occur, pulmonary HL occurred as an iso (primary pulmonary HL, PPHL) re uncommon observation. 1-6 A case of PPH a mediastinal tumour is herein reported discussion on the most important concerns during the diagnostic process. Case Report. The patient was a 27-y smoker woman who kept under our attenti mediastinal enlargement incidentally disc standard thoracic radiography performed vague pulmonary symptomatology, cons cough and mild dyspnoea on e comprehensive diagnostic work-up was Routine laboratory analysis showed n findings, with the exception of a slight leukocytosis. Moreover, all common viru including HIV, were ruled out by spec em URNAL OF HEMATOLOGY AND INFECTIO www.mjhid.org ISSN 2035-3006 Lymphoma Simulating a Mediastin Pasquale Niscola 2 , Malgorzata Monika Trawinska 2 , E ssio Perrotti 2 and Giuseppe Santeusanio 1 tal, Rome (Italy) spital, Rome (Italy) enio Hospital, Rome (Italy) spital, Rome (Italy) ematology Unit, S. Eugenio Hospital, Piazzale del 0, Fax: +390651003241. E-mail: pniscola@gmail.com eclared that no competing interests exist. 5(1): e2013013, DOI: 10.4084/MJHID.2013.013 id.org/article/view/11220 buted under the terms of the Creative Commons which permits unrestricted use, distribution, and reprod with primary pulmonary Hodgkin Lympho ts rarity and the diagnostic concerns encounte infiltration of ma (HL) may olated tumour epresents an HL simulating with a brief s encountered year-old non- ion because a covered by a because of a sisting of dry exertion. A s performed. no abnormal t neutrophilic us infections, cific antibody tests. A computed tomography (C revealed a pulmonary mass (8 cm middle lobe of right lung; this anterior-medium mediastinum mediastinal neoplasm. No finding pulmonary infiltrates or hilar an nodes involvement were detected mediastinoscopy, a lymphoprolife highly suspected; however, the pa taken during an excision biopsy anterior mediastinotomy was histological analysis. Therefore thoracoscopy (VATS) with intrao performed. VATS showed a so confined to the lung and revealed mediastinal invasion, as well as n pleura and the anterior chest wa examination (Figure 2) revealed l a nodular growth with thick co nodules showed a dense cellular in OUS DISEASES nal Tumour: an Edoardo Mercadante 3 , ll’Umanesimo n° 10, m s Attribution License duction in any medium, oma simulating a ered by us. CT) scan of the chest m in diameter) in the mass reached out to m, simulating a gs consistent with any nd mediastinal lymph d (Figure 1). On the erative neoplasm was athological specimens performed during an unsuitable for a e, a video-assisted operative biopsy were olitary nodular mass d the absence of any no extension into the all. The microscopic lung tissue effaced by ollagen bands. Such nfiltrate composed of