Effects of arsenic on adipocyte metabolism: Is arsenic an obesogen? Zeltzin A. Ceja-Galicia a, b, 1 , Alberto Daniel a, c, 1 , Ana María Salazar a , Pablo P  anico a, d , Patricia Ostrosky-Wegman a , Andrea Díaz-Villase ~ nor a, * a Instituto de Investigaciones Biom edicas, Universidad Nacional Aut onoma de M exico, Mexico City, 04510, Mexico b Maestría en Ciencias de la Producci on y Salud Animal, Unidad de Posgrado, Universidad Nacional Aut onoma de M exico, Mexico City, 04510, Mexico c Maestría en Ciencias Biol ogicas, Unidad de Posgrado, Universidad Nacional Aut onoma de M exico, Mexico City, 04510, Mexico d Doctorado en Ciencias Biom edicas, Unidad de Posgrado, Universidad Nacional Aut onoma de M exico, Mexico City, 04510, Mexico article info Article history: Received 2 February 2017 Received in revised form 5 May 2017 Accepted 5 May 2017 Available online xxx Keywords: Arsenic Adipose tissue Obesity Obesogen Adipogenesis Lipolysis Adipokines Glucose uptake abstract The environmental obesogen model proposes that in addition to a high-calorie diet and diminished physical activity, other factors such as environmental pollutants and chemicals are involved in the development of obesity. Although arsenic has been recognized as a risk factor for Type 2 Diabetes with a specific mechanism, it is still uncertain whether arsenic is also an obesogen. The impairment of white adipose tissue (WAT) metabolism is crucial in the onset of obesity, and distinct studies have evaluated the effects of arsenic on it, however only in some of them for obesity-related purposes. Thus, the known effects of arsenic on WAT/adipocytes were integrated based on the diverse metabolic and physiological processes that occur in WAT and are altered in obesity, specifically: adipocyte growth, adipokine secretion, lipid metabolism, and glucose metabolism. The currently available information suggests that arsenic can negatively affect WAT metabolism, resulting in arsenic being a potential obesogen. © 2017 Elsevier B.V. All rights reserved. Contents 1. Introduction ....................................................................................................................... 00 2. Effects of arsenic on adipocyte growth ................................................................................................ 00 3. Effects of arsenic on adipokine secretion .............................................................................................. 00 4. Effects of arsenic on lipid metabolism of adipocytes .................................................................................... 00 5. Effects of arsenic on glucose metabolism of adipocytes ................................................................................. 00 6. Concluding remarks ................................................................................................................ 00 Conflict of interest ............................................................. .................................................... 00 Acknowledgments ................................................................................................................. 00 References ........................................................................................................................ 00 1. Introduction High body-mass index (BMI) is an important risk factor for type 2 diabetes (T2D), as well as other metabolic diseases and some types of cancers. From 1975 to 2014, the global age-standardized BMI has increased from 21.9 kg/m 2 to 24.2 kg/m 2 (Collaboration, 2016), and between 1980 and 2008, the prevalence of worldwide obesity rose from 4.8% to 9.8% in men and from 7.9% to 13.8% in * Corresponding author. Instituto de Investigaciones Biom edicas, Departamento de Medicina Gen omica y Toxicología Ambiental, Universidad Nacional Aut onoma de M exico, Mexico City, 04510, Mexico. E-mail address: diaz.villasenor@iibiomedicas.unam.mx (A. Díaz-Villase~ nor). 1 These authors contributed equally to this work, listed alphabetically by last names. Contents lists available at ScienceDirect Molecular and Cellular Endocrinology journal homepage: www.elsevier.com/locate/mce http://dx.doi.org/10.1016/j.mce.2017.05.008 0303-7207/© 2017 Elsevier B.V. All rights reserved. Molecular and Cellular Endocrinology xxx (2017) 1e8 Please cite this article in press as: Ceja-Galicia, Z.A., et al., Effects of arsenic on adipocyte metabolism: Is arsenic an obesogen?, Molecular and Cellular Endocrinology (2017), http://dx.doi.org/10.1016/j.mce.2017.05.008