Lawale et al Journal of Drug Delivery & Therapeutics. 2019; 9(1):159-164 ISSN: 2250-1177 [159] CODEN (USA): JDDTAO Available online on 15.01.2019 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-18, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non-commercial use, provided the original work is properly cited Open Access Research Article Permanganatic oxidation of neomycine sulphate salt in basic media: a kinetic study Narayan V. Lawale 1 , Bhagwan Singh Dobhal 2 , Sandip Singh Gaur 3 and Rajendra Pardeshi* 4 1 Moreshwar Arts, Commerce and Science College, Bhokardan Dist Jalna, Maharashtra, India 2 Badrinarayan Barwale, Arts, Commerce and Science College, Jalna. Maharashtra, India 3 Sant Ramdas Arts, Science and commerce College Ghansawangi. Dist Jalna. Maharashtra, India 4 Sant Ramdas Arts, Science and commerce College Ghansawangi. Dist Jalna. Maharashtra, India ABSTRACT Permanganatic oxidation of Neomycine sulphate salt has been studied at different temperatures using spectrophotometer under alkaline conditions. The effect of variation of substrate Neomycine sulphate salt (NS), oxidant (KMnO4) and NaOH was studied under pseudo first order reaction conditions. The effect of different salts and solvents on oxidation of NS was also studied. The reaction was found to be first order with respect to oxidant, substrate and NaOH.. Keywords: Neomycine sulphate salt (NS), KMnO4 , permanganatic oxidation, alkaline permanganate Article Info: Received 23 Nov 2018; Review Completed 04 Jan 2019; Accepted 06 Jan 2019; Available online 15 Jan 2019 Cite this article as: Lawale NV, Dobhal BS, Gaur SS, Pardeshi R, Permanganatic oxidation of neomycine sulphate salt in basic media: a kinetic study, Journal of Drug Delivery and Therapeutics. 2019; 9(1):159-164 DOI: http://dx.doi.org/10.22270/jddt.v9i1.2201 *Address for Correspondence: Rajendra Pardeshi, Sant Ramdas Arts, Science and commerce College Ghansawangi. Dist Jalna. Maharashtra, India INTRODUCTION In recent years there is increasing trends to study the oxidation of medicinal drugs by various oxidizing agents 1-3 . This is because, it is necessary to remove the pharmaceutical ingradient present in the the waste water. The oxidative degradation is one of the suitable methods. It will oxidize the medicinal drugs to some nontoxic materials. Further, it is also necessary to know oxidation for assessing the stability of drug. Neomycine sulphate is an antibiotic medicinal drug, with molecular formula C20H46O18 xH2SO4 and molecular weight 615 g mol -1 . Potassium permanganate is a widely used oxidant, works in acidic, basic and in neutral media. It has +2 to +7 oxidation states. In the present investigation, we report here with oxidation of neomycine sulphate by potassium permanganate under basic condition. EXPERIMENTAL For the present study distilled water was prepared in the laboratory using all quick fit glass assembly distillation units. A pinch of KOH and KMnO4 was added the pH of the distilled water was monitor. All solutions were prepared in double distilled water a stock solution 0.01M KMnO4 was prepared and standardized using oxalate. A thermostat of locally assembled Dinesh make was used to maintain temperature constant. Neomycine sulphate salt was purchased from local Chemical traders of Hi-media chemicals. All kinetic runs were carried out in thermostat by champing the conditions such as variation in oxidant, variation in substrate, variation in NaOH, effect of temperature, effect of salt and effect of solvent. All kinetic runs were carried out using double beam spectrophotometer (ELICO SL 210) at 525 nm. Equimolar solution of substrate and oxidant was taken in beaker. A small quantity of base was added the solution was left overnight. Precipitate was not observed and it was not possible to obtain product mass. RESULT AND DISCUSSION Effect of variation of Substrate (NS) concentration:- To study the effect of variation of concentration of substrate the sets are prepared in which the concentration of NS was varied from 1 x 10 -3 to 9 x 10 -3 M, keeping constant concentration of [KMnO4]= 1 x10 -3 M, [NaOH] = 1 M . As the reaction has been studied under pseudo first order condition pseudo first order rate constants were calculated. It is clear