Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research __________________________________________________ ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2010, 2(4):106-111 106 Antimicrobial Activity Of Thiosemicarbazone Derivatives Of Lawsone And Its Nickel Complexes *Sanjay Gaikwad and Charushila Gaikwad Department of Chemistry, Post-graduate and Research Centre, Bharatiya Jain Sanghatana College, Wagholi,.Pune, India ______________________________________________________________________________ ABSTRACT Thiosemicarbazone derivative at 1 and 2 position of the Biologically important Lawsone ( 2- hydroxy-1,4-naphthalenedione ) have been synthesized. This possesses a powerful chelating ability, appreciable analytical utility and significant biological activity. Metal complexes of TSCND with Ni(II) metal have been synthesized and studied with the help of spectral analysis and elemental analysis. The antimicrobial activity of the ligands and their metal complexes against bacteria and fungus has been carried out. It is found that the metal complexes have higher activities than those of free ligands. Keywords: Lawsone, Thiosemicarbazone derivative, Nickel (II) complex and microbial Studies ______________________________________________________________________________ INTRODUCTION Naturally occurring quinones have several different roles in organisms, they are functional constituents of several biochemical systems ( e.g. ubiquinones and vitamin K 1 ), they are dyes or they act as defensive compounds. Quinines are used as pharmaceuticals. The exposure of cell to quinonidal compounds may lead to several deleterious consequences. Chronic exposure to quinones may be carcinogenic; several quinones are mutagenic in the Ames test as well as to cultures of eukaryotic cells. Acute exposure to quinones may cause cell death. Several anticancer drugs contain the quinone part ( figure 1) and adramycin, a synthetic quinone is useful in cancer chemotherapy .