Accepted Manuscript Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity Lara A. Zimmermann, Milene H. de Moraes, Rafael da Rosa, Eduardo B. de Melo, Fávero R. Paula, Eloir P. Schenkel, Mario Steindel, Lílian S.C. Bernardes PII: S0968-0896(18)31167-2 DOI: https://doi.org/10.1016/j.bmc.2018.08.025 Reference: BMC 14512 To appear in: Bioorganic & Medicinal Chemistry Received Date: 21 June 2018 Revised Date: 7 August 2018 Accepted Date: 17 August 2018 Please cite this article as: Zimmermann, L.A., de Moraes, M.H., da Rosa, R., de Melo, E.B., Paula, F.R., Schenkel, E.P., Steindel, M., Bernardes, L.S.C., Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity, Bioorganic & Medicinal Chemistry (2018), doi: https:// doi.org/10.1016/j.bmc.2018.08.025 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.