561 INTRODUCTION The outbreak of the COVID-19 pandemic can be attributed to the spread of a disease called COVID-19 or Coronavirus 2 (SARS-CoV-2), which causes severe acute respiratory syndrome (Scheller et al., 2020). The ongoing pandemic has brought about challenges that have been dealt with taking measures such as prolonged or intermittent social distancing, which may even be necessary until 2022 (Kissler et al., 2020). Furthermore, scientists have pointed out that the virus has some weak points (Scheller et al.), aside from describing its incubation period of approximately 5 days (Lauer et al., 2020) and finding out that it makes more viruses in the nasopharynx (Hui et al., 2020). Three issues it is necessary to discuss to develop preventive actions against SARS-CoV-2 Infection will be listed here below: 1. Can nasal spray devices be of any use to stop SARS-CoV-2 replication at the respiratory system, especially at nasopharynx? 2. Will it be possible to find any spray that will be able to inactivate SARS-CoV-2 in the ocular conjunctiva and periocular tissues/elements? 3. Are there bio-tolerated chemical materials capable of effectively inactivating SARS-CoV-2 at the respiratory system and oral/ocular/periocular mucose? It has been elucidated that a SARS-CoV-2 contagion route corresponds to the inhalation of the virus (Pervushin et al., 2009) and it has also been reported that it can be transmitted through the eye (Coroneo, 2020). For this reason, medications via nasal/eye spray and inhalers could fulfill the function of inactivating SARS-CoV-2, since they could reach the levels where this virus develops at a less aggressive stage, aiming at anatomical areas such as the ocular conjunctiva, periocular tissues, pharynx and the respiratory tree reaching its deepest areas. Due to the previously mentioned reasons, the following hypothesis can be presented: The use of Int. J. Odontostomat., 14(4):561-563, 2020. Can a Nasal/Oral/Ocular Spray Inactivate and Prevent SARS-CoV-2 infection? A hypothesis ¿Puede un Spray Nasal/Oral/Ocular Inactivar y Prevenir la Infección por SARS-CoV-2?: Una hipótesis Edgardo Fuentes 1 & Matías Santos-López 2 FUENTES, E. & SANTOS-LÓPEZ, M. Can a nasal/oral/ocular spray inactivate and prevent SARS-CoV-2 infection? A hypothesis. Int. J. Odontostomat., 14(4):561-563, 2020. ABSTRACT: The COVID-19 pandemic has created challenges that have been dealt with adopting measures such as prolonged or intermittent social distancing, which may even be necessary until 2022. Furthermore, it has been described that a SARS-CoV-2 contagion route corresponds to the inhalation of the virus. Medications via nasal/eye spray and inhalers, therefore, could fulfill the function of inactivating SARS-CoV-2. Due to the abovementioned reasons, we suggest the following hypothesis: The use of Ocular/Nasal/Oral sprays could prevent the infection and the further spread of SARS-CoV-2. KEY WORDS: COVID-19, SARS-CoV-2, sprays, infection. 1 Faculty of Health Sciences, Universidad Autónoma de Chile, Chile. 2 Faculty of Dentistry, Universidad Finis Terrae, Chile.