This is a preprint draft. The published article can be found at: https://doi.org/10.1016/j.conbuildmat.2022.127270 Please cite this paper as: Saleh E., Tarawneh A., Naser M.Z., Abedi M., Almasabha G., (2021). “You Only Design Once (YODO): Gaussian Process-Batch Bayesian Optimization framework for Mixture Design of Ultra-High-Performance Concrete”. Construction and Building Materials. https://doi.org/10.1016/j.conbuildmat.2022.127270 1 You Only Design Once (YODO): Gaussian Process-Batch Bayesian Optimization 1 framework for Mixture Design of Ultra-High-Performance Concrete 2 Eman Saleh 1 , Ahmad Tarawneh 2 , M.Z. Naser 3 , M. Abedi 4 , Ghassan Almasabha 5 3 1 Assistant Professor, Civil Engineering Department, Faculty of Engineering, The Hashemite University, P.O. box 4 3301127, Zarqa 13133, Jordan; Email: emanf_yo@hu.edu.jo 5 2 Assistant Professor, Civil Engineering Department, Faculty of Engineering, The Hashemite University, P.O. box 6 3301127, Zarqa 13133, Jordan; Email: ahmadn@hu.edu.jo 7 3 School of Civil and Environmental Engineering & Earth Sciences, Clemson University, Clemson, SC, USA 8 3 AI Research Institute for Science and Engineering (AIRISE), Clemson University, Clemson, SC, USA. 9 E-mail: mznaser@clemson.edu, Website: www.mznaser.com 10 4 M. Abedi, Ph.D. student, School of Civil and Environmental Engineering & Earth Sciences, Clemson University, 11 Clemson, SC, USA 12 5 Assistant Professor, Civil Engineering Department, Faculty of Engineering, The Hashemite University, P.O. box 13 3301127, Zarqa 13133, Jordan; Email: ghassans@hu.edu.jo 14 GRAPHICAL ABSTRACT 15 16 17 18 19 Existing dataset or initial dataset Batch Bayesian optimization Carry out Experiments Augment the dataset by adding the new mixture design from experiments GP modeling and validation Selection from the batch (cost, practicality, …