S624 Indian Journal of Pharmaceutical Education and Research |Vol 53 | Issue 4 (Suppl) | Oct-Dec, 2019 Original Artcle www.ijper.org One Step Towards: The Synthesis of Optimized Coumarin Derivatives as an Anti-HIV Agent Vikas Kumar 1, *, Indra Prashad Pandey 1 , Jainendra Jain 2 , Ram Babu Tripathi 2 1 Research Scholar of Uttarakhand Technical University, Department of Chemistry, Uttarakhand, INDIA. 2 Ram-Eesh Institute of Vocational and Technical Education, Noida, Uttar Pradesh, INDIA. ABSTRACT The development for the sustainable approach was a key ingredient for the research, especially in the feld of drug development against HIV. Several attempts have been made in the positive direction for the treatment of fatal disease, however the suitable lead was missing in the therapeutically arena. Many different kinds of natural products, including coumarins, have been found to be active in the various anti-HIV models and still investigation is undergoing. The present fnding demonstrates the synthesis of the best ft compound, which was revealed in the previously published research. The in- silico study is further justifed with the synthetic approach and their characterization. The in-silico based optimized coumarin structure have been tried to get closer to the drug discovery process, where in the future it will be evaluated for the in-vitro / in-vivo biological screening to get the lead molecule for the treatment of HIV. The objective of this research is to evaluate data on coumarins’ potent activity with respect to the inhibition of HIV-reverse transcriptase; Structural modifcation is a powerful tool to increase the potential of bioactive principles. By applying scientifc expertise and modern scientifc technology, new single compounds will assuredly be developed as potent anti- HIV candidates for world-class new drug development. Key words: Coumarins, HIV integrase inhibitors, Protease inhibitors, Reverse transcriptase inhibitors, QSAR. DOI: 10.5530/ijper.53.4s.158 Correspondence: Mr. Vikas Kumar, Research Scholar of Uttara- khand Technical University, Department of Chemistry, Uttarakhand, INDIA. Phone: +91 8894001645 E-mail: vikasnagaich@gmail. com Submission Date: 28-06-2019; Revision Date: 03-08-2019; Accepted Date: 26-09-2019 INTRODUCTION (HIV) Human Immunodefciency Virus induces disease in humans that is known as AIDS (acquired immunodefciency syn- drome). 1 Principal AIDS cases were regis- tered in 1981 when the Centers for Ailment Management (CDC) has identifed a bunch of pneumocystis carinii group of fve gay men in Los Angeles In 1982, the authority given the name of AIDS to this disease. 2 There are now two sort of HIV infection, HIV 1 and HIV 2 as infects, which was reported by Luc Montagnier in 1983 and 1986. HIV 1 disease had come from Congo in 1959 and 1960. 3 While HIV-2 could be produced from mostly geographical pitchy catarrhine (Atys from Cercocebus). 4 In comparison with HIV-2, HIV-1 is extreme virulent and the most commonly found globally in HIV medicines. 5 At the stage of development of HIV is triggered when host cells, particularly immune system cells, are associated with T lymphocytes, macrophages and cells of nerve fber. 6 It has led to a reduction of CD4 + T cell levels through three primary processes: immediate bacterial killing of infected cells, a boost in cell mortality in affected cells and the killing by CD8 of tainted CD4 + T neurons that can identify cells produced by the viruses. CD4 + T tissues are damaged and can cause damage to the immune system’s function and defciency. Normal CD4+T concentra- tions are sometimes between 800 and one, 200cells/mm 3 in safe uninfected popula- tions. 7 The advance of HIV disease lowers the amount of CD4 + T neurons and once below 200/mm 3 , people become consider- ably exposed to the diseases and opportu-