Research Article BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population Deepti Bhatt, 1 Amit Kumar Verma, 1 Prahalad Singh Bharti, 2 Yamini Goyal, 1 Mohammed A. Alsahli, 3 Ahmad Almatroudi , 3 Arshad Husain Rahmani , 3 Saleh Almatroodi, 3 Prakash C. Joshi, 4 Mohammad Mahtab Alam, 5 Irfan Ahmad, 6 Gaffar Sarwar Zaman, 6 and Kapil Dev 1 1 Department of Biotechnology, Jamia Millia Islamia, New Delhi, India 2 Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India 3 Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia 4 Department of Zoology and Environmental Sciences, GKV, Haridwar, India 5 Department of Basic Medical Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia 6 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia Correspondence should be addressed to Kapil Dev; kdev@jmi.ac.in Deepti Bhatt and Amit Kumar Verma contributed equally to this work. Received 9 September 2020; Revised 13 January 2021; Accepted 14 February 2021; Published 25 February 2021 Academic Editor: Peter F. Lenehan Copyright©2021DeeptiBhattetal.isisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Breast cancer is the most common carcinoma in women worldwide. e present case-control study was aimed to examine the association of BCL-2 (-938C> A), BAX (-248G > A), and HER2 (I655V i.e. A > G) polymorphisms with breast cancer risk in Indianpopulation.isstudyenrolled117breastcancercasesand104controls.BCL-2(-938C > A),BAX(-248G > A),andHER2 Ile655Val polymorphisms were screened by PCR-RFLP method. ere was no significance difference in the allelic and genotype frequency of the BCL-2 (-938C > A) and BAX (-248G > A) polymorphisms between cases and controls. In relation to HER2 Ile655Val polymorphism, the statistical analysis of observed genotypic frequencies showed significant association (p-0.0059). Compared to Ile/Ile (A/A) genotype, frequency of Ile/Val (A/G) genotype was significantly higher among cases than in control group and observed to increase the breast cancer risk (OR, 2.43; 95%CI, 1.32–4.46; p-0.004). e frequency of Val (G) allele was significantlyhigherincasesascomparedtocontrols(6.83%vs2.88%,resp.).ComparedtoIle(A)allele,significantincreaseinthe riskofbreastcancerwasobservedwithVal(G)allele(OR,2.21;95%CI,1.35–3.63; p-0.0016).Weobservedsignificantassociation between HER2 Ile655Val polymorphism and breast cancer risk under the dominant (OR � 2.52; 95% CI:1.41–4.51; p-0.001) and codominant(OR,2.24;95%CI:1.23–4.09;p-0.008)model.Inourstudy,BCL-2(-938C > A)andBAX(-248G > A)polymorphism werenotfoundtobeassociatedwithbreastcancerrisk.ispresentstudyforthefirsttimeshowssignificantassociationofHER2 Ile655Val polymorphism with risk of breast cancer in Indian population. erefore, we suggest that each population need to evaluate its own genetic profile for breast cancer risk that may be helpful for better understanding the racial and geographic differences reported for breast cancer incidence and mortality. 1. Introduction Breast cancer is the leading cause of cancer-related deaths and it is the most common type of cancer among women worldwide [1]. In India, projected number of breast cancer cases is 179,790 in the year 2020 and will comprise approximately10%ofallcancers[2].Variousriskfactorsare associated with the development, pathogenesis, and pro- gression of breast cancer, including genetic, environmental, biological, and lifestyle factors [3]. e relation between the occurrence of a cancer and the existence of genetic alter- ations is now well established [4]. For better understanding Hindawi Journal of Oncology Volume 2021, Article ID 8865624, 8 pages https://doi.org/10.1155/2021/8865624