November 2019 · Volume 8 · Issue 11 Page 4400 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Ravi AK et al. Int J Reprod Contracept Obstet Gynecol. 2019 Nov;8(11):4400-4405 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 Original Research Article Fetal growth in low-risk Indian population at a tertiary centre and its comparison with INTERGROWTH-21 standards: a prospective cohort study Anoosha K. Ravi 1 , Krishna Agarwal 1 *, Siddarth Ramji 2 , Sreenivas Vishnubhatla 3 INTRODUCTION The sources for percentile charts to guide intrauterine growth are normograms constructed from population in USA or Europe (e.g.; Alexander et al, Brenner et al,) or from mothers with known constraints to growth. 1,2 Similar to the WHO reference standards available for growth monitoring from 0 to 5 years of age, a global initiative was taken to develop global reference standards for intrauterine fetal growth monitoring and was published as INTERGROWTH 21; International fetal and new-born growth consortium for the 21 st century. 3,4 This was a prescriptive study involving affluent educated mothers. With this available international standard, the fetal growth of local population is studied which constitutes mostly socioeconomically disadvantaged mothers and thence the study will impress upon how fetuses from non-affluent population grow as compared to the international growth standards. ABSTRACT Background: The objective of this study was to compare the fetal growth pattern in low risk Indian population with the INTERGROWTH-21 standards. Methods: Low risk women were enrolled at 10 to 20 weeks of gestation and followed up until delivery. An experienced operator performed abdominal ultrasound every 5±1 week and measured biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL) of the fetus. Newborn anthropometric measurements were taken within 12 hours of childbirth. Results: A total of 126 healthy women, enrolled at mean gestation of 16.8±1.6 weeks, completed the follow up until delivery. None of the participants developed any major obstetric or medical morbidity. The study subjects showed lower mean z scores for BPD (-0.7±1.3), HC (-0.4±1.3) and AC (-0.4±1.3) but a higher mean z-score for FL (0.3±1.7) as compared to INTERGROWTH-21 standards. From 1 st through 5 th visit, the z scores for BPD and HC improved whereas declined for AC and FL. Conclusions: The fetal growth in non-affluent healthy Indian women had a lower fetal growth compared to INTERGROWTH-21 standards. Keywords: Abdominal circumference, Biparietal diameter, Femur length, Intrauterine fetal growth, Percentile charts, Ultrasound parameters DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20194864 1 Department of Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, India 2 Department of Neonatology, Maulana Azad Medical College, New Delhi, India 3 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India Received: 09 September 2019 Accepted: 04 October 2019 *Correspondence: Dr. Krishna Agarwal, E-mail: drkrishna.agarwal@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.