_____________________________________________________________________________________________________ ⱷ Lecturer/MDS trainee, # Assistant professor and HOD, † C. E. O, ‡ Sr. research officer, ¥ Lecturer, *Corresponding author: E-mail: ayesha.hanif@zu.edu.pk, ayeshahanif@hotmail.com; Journal of Pharmaceutical Research International 34(42A): 19-27, 2022; Article no.JPRI.88384 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Effect of Non-surgical Periodontal Therapy on the Clinical Periodontal Inflammatory Parameters in β-Thalassemia Major (TM-β) Patients with Gingivitis Ayesha Hanif a*ⱷ , Saima Quraeshi a# , Asim Qidwai b† , Moazzam Ali Shahid c‡ , Soban Qadir Khan d¥ , Komal Khan e and Javairia Waqasi e a Department of Periodontology, Ziauddin College of Dentistry, Karachi, Pakistan. b Hemoglobinopathies, AMTF Helping Blood Disorder Program, Karachi, Pakistan. c Department of Biochemistry, Ziauddin University, Karachi, Pakistan. d Biostatistics and Department of Dental Education, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. e BDS, Ziauddin College of Dentistry, Karachi, Pakistan. Authors’ contributions This work was carried out in collaboration among all authors. Author AH was the primary author and conducted the research, wrote the manuscript and collected data. Authors AQ, MAS and SQ supervised and guided the project, revised the manuscript. Authors KK and JW assisted in data collection, patient screening and clinical therapy and management. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2022/v34i42A36291 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/88384 Received 05 April 2022 Accepted 13 June 2022 Published 15 June 2022 ABSTRACT Background: Increased prevalence of gingival diseases in thalassemia patients has been consistently reported. In diseases with neutrophil dysfunctions, periodontal tissue is lost very rapidly. β-thalassemia major (TM- β) patients exhibit defective neutrophils and macrophages. Therefore, supplementary gingival inflammation is detrimental to periodontal tissues in these patients. This warrants attention to specialized oral health care intervention in these patients. This is Original Research Article