rehabilitation paradigm (TDS-HM) that uses a Tongue Drive System (TDS) to control a robotic device (HandMentor: HM), encouraging active learning through a game-like user interface. We hypothesize TDS-HM training will improve motor performance, reduce UE impairment, and improve quality of life in stroke survivors. Design: Single-group prospective design. Setting: All assessments and interventions were completed in a university laboratory setting. Participants: Six stroke survivors (60.8Æ11.6 years old) with UE hemi- paresis from unilateral stroke (21Æ9.26 months post stroke). Interventions: Fifteen, two-hour sessions of TDS-HM training over five weeks. Main Outcome Measure(s): Kinematic motor performance was evaluated by root mean squared error (RMSE). Wolf Motor Function Test (WMFT), Fugl-Meyer Motor Assessment (FMA), and active and passive range of motion (ROM) assessed various levels of functional capacity. The Stroke Impact Scale (SIS) was used to assess quality of life. Results: Analysis of RMSE revealed significant improvements in tracking performance (52.87%, p Z 0.007) that transferred to clinically and sta- tistically relevant improvements in mean FMA and subsets of SIS scores. Participants were able to complete the WMFT in less time and were able to successfully complete more tasks. Participants gained both active and passive ROM, although only passive ROM was statistically signifi- cant (pZ0.034). Conclusion/Discussion: This pilot study demonstrates that the TDS-HM elicits improvements in motor performance that transfer to reduced UE impairments and improvements in quality of life for stroke survivors. Key Words: Robot-Assistive Rehabilitation, Stroke, Upper-Extremity, Assistive-Technology Disclosures: None. Research Poster 326688 WITHDRAWN Research Poster 300058 Comparative Analysis of Unsafe Driving Risk in Medical Conditions Sanghee Moon (University of Kansas Medical Center), Maud Ranchet, Mark Tant, Abiodun Akinwuntan, Hannes Devos Research Objectives: To compare risks of unsafe driving in patients with medical conditions. Design: Cohort study. Setting: Center for Evaluation of Fitness to Drive and Car Adaptations, Belgian Road Safety Institute, Brussels, Belgium. Participants: 6,584 patients with various medical conditions who were referred for a driving evaluation. Interventions: Not applicable. Main Outcome Measure(s): Risks of unsafe driving including physician’s fitness-to-drive recommendation, comprehensive fitness-to-drive decision, motor vehicle crash history, and traffic violation history. Results: Risks of unsafe driving were significantly different across med- ical conditions (p < 0.001 for all outcome measures). Patients with neurological conditions comprised the majority of the database (74%), but were not at highest risk for unsafe driving. Patients with psychiatric conditions or substance abuse did worse on most driving safety outcomes, despite their low representation in the total sample (6% and 1%, respectively). Conclusion/Discussion: The risks of unsafe driving varied greatly across medical conditions. Sensitization campaigns, education, and medical guidelines for physicians and driver licensing authorities are warranted to identify patients at risk, especially for those with psychiatric conditions and substance abuse problems. Key Words: Automobile Driving, Traffic Accidents, Psychiatry, Substance- Related Disorders Disclosures: None. Research Poster 305077 Comparative Effectiveness Trial between a Clinic- and Home-Based Exercise Intervention for Multiple Sclerosis Whitney Neal (Lakeshore Foundation), Hui-Ju Young, Tapan Mehta, Mohanraj Thirumalai, Tracy Tracy, Emily Riser, James Rimmer Research Objectives: To explain the methodology of the TEAMS (Tele- Exercise And Multiple Sclerosis) project (PCORI Award #MS-1511- 33653) which aims to compare two delivery forms of the same evidence- based neurorehabilitation/exercise intervention targeting people with multiple sclerosis (MS). Design: 48-week cluster-randomized control trial. Data collected at baseline, post-intervention (12 weeks), 24 weeks, and 48 weeks. Partici- pants also complete weekly and biweekly self-report measures for physical activity, pain, fatigue and quality of lifevia an Interactive Voice Response (IVR) system. Setting: Thirty-four rehabilitation clinics across Alabama and Mississippi. Participants: Adults with MS (Patient Determined Disease Steps [PDDS] score: 0-6) between the ages of 18 and 70 years. Interventions: The intervention consists of a 60-minute Complementary Alternative Medicine (CAM) program that includes yoga, Pilates and dual- functioning exercises, which is delivered 2 times per week for the first 8 weeks and 1 time per week for the following 4 weeks, either at a clinic with a therapist (DirectCAM) or at home via videos (TeleCAM). At the end of week 12, participants from both groups will be asked to continue the program in their home for up to 1 year post-intervention using handouts (DirectCAM) and the videos (TeleCAM). Main Outcome Measure(s): Primary outcomes measures were selected based on stakeholder input and include pain, fatigue, quality of life, and physical activity. Secondary outcome measures include anthropometrics, the Berg Balance, timed up and go, 6-minute walk/push test, and grip strength. Results: Anticipated results include greater improvements in health and function outcomes, quality of life and physical activity level, as well as greater reductions in pain and fatigue in TeleCAM when compared to DirectCAM. Conclusion/Discussion: Not applicable at this time. Key Words: Multiple Sclerosis, Telerehabilitation, Yoga, Physical activity Disclosures: None. Research Poster 296882 Comparative Efficacy of Clinic-Based and Telerehabilitation Application of Mckenzie Therapy in Low-Back Pain Chidozie Mbada (Obafemi Awolowo University), Mistura Olaoye, Olusola Ayanniyi, Olubusola Johnson, Adesola Odole, Olumide Dada Research Objectives: To compare the effect of Telerehabilitation-Based McKenzie Therapy (TBMT) and Clinic-Based McKenzie Therapy (CBMT) among patients with Chronic Low-Back Pain (CLBP). Design: Randomized-controlled trial. Setting: Two government-funded public hospitals in Nigeria. e46 Research Posters www.archives-pmr.org