290 Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Cilt: 5, Sayı: 4, 2015 / Journal of Marmara University Institute of Health Sciences Volume: 5, Number: 4, 2015 - http://musbed.marmara.edu.tr Squamous Cell Carcinoma of The Gingiva: A Case Report and Literature Review Gaye Keser 1 , Filiz Namdar Pekiner 1 , Semih Özbayrak 1 , Canan Alatlı 2 1 Department of Oral Diagnosis and Radiology, Faculty of Dentistry, Marmara University, Istanbul - Turkey 2 Department of Oncological Cytology, Institute of Oncology, Istanbul University, Istanbul - Turkey Yazışma Adresi / Address reprint requests to: Gaye Keser Department of Oral Diagnosis and Radiology, Faculty of Dentistry, Marmara University, Istanbul - Turkey Elektronik posta adresi / E-mail address: gayegamze@hotmail.com Kabul tarihi / Date of acceptance: 15 Temmuz 2015 / July 15, 2015 ÖZET Gingivanın skuamöz hücreli karsinomu: Vaka sunumu ve literatür taraması Skuamöz hücreli karsinom (SCC) oral kavitede en sık görülen ve farklı klinik belirtiler ile karakterize malign epitelyal bir neoplazmdır. SCC displastik oral skuamöz epitelinden doğmaktadır. SCC patogenezi göz önüne alınırsa oluşan lezyon için pürüzsüz ve sağlam bir yüzey olağan değildir. 52 yaşında kadın hasta dişetinde büyüme şikayeti ile Marmara Üniversitesi Diş Hekimliği Fakültesi Oral Diagnoz Kliniğine yönlendirl- miştir. Hastanın tıbbi anamnezinde herhangi bir sistemik hastalık olma- dığı öğrenilmiştir. Ayrıca lenfadenopati tespit edilmemiştir. Sol maksiller birinci molar bölgede bukkal ve palatinal mukozada verrüköz bir görün- tü oluşturan lezyon ve dokuda hipertrofi izlenmiştir. Klinik muayeneye ek olarak ilgili bölgeden önce smear biyopsi ve sonrasında ise insizyonel biyopsi alınmıştır. Histopatolojik inceleme sonucunda lezyonun ‘skua- möz hücreli karsinom’ tanısı ile malign karakterde olduğu saptanmıştır. Sonuç olarak hasta lezyonun cerrahi operasyon ile elimine edilmesi için Kulak, Burun, Boğaz (KBB) departmanına yönlendirilmiştir. Anahtar sözcükler: Skuamöz hücreli karsinom, oral diagnoz, histopato- lojik değerlendirme ABSTRACT Squamous cell carcinoma of the gingiva: a case report and literature review Squamous cell carcinoma (SCC) is the most frequent epithelial malignancy of the oral cavity which is characterized by variable clinical manifestations. It arises from dysplastic oral squamous epithelium. By considering the pathogenesis of SCC, the smooth and intact surface for this lesion is not usual. A 52-year-old female patient was refered to Marmara University, Faculty of Dentistry, Oral Diagnosis Clinic with a chief complaint of generalized swelling of the gingiva. There was neither significant medical and family history nor any history of medication. No bleeding was reported and submandibular lymphadenopathy (LAD) was noted. Buccal and a palatinal mucosal tissue of left maxillary first molar had a verrucous appearance. In addition to clinical examination, a smear biopsy and then incisional biopsy was performed and histopathological examination revealed the lesion had a malign characterization with a diagnosis of ‘squamous epithelium carcinoma’. Consequently, the patient was referred to Ear, Nose and Throat (ENT) department where the lesion was treated by surgery. Key words: Squamous cell carcinoma, oral diagnosis, histopathological examination MÜSBED 2015;5(4):290-295 Olgu Sunumu / Case Report INTRODUCTION Squamous cell carcinoma (SCC) is an invasive epithelial neoplasm, with variable degrees of squamous differentiation. This neoplasm can occur with or without keratinization. SCC originates at the level of the keratinized stratified squamous epithelium (skin) or non- keratinized (uterine exocervical, oral mucosa, esophageal) mucosa. The squamous metaplasia areas such as uterine endocervix or trachea-bronchial tree, are regions where SCC can also be involved. This neoplasm infiltrates the surrounding tissues creating rapid metastasis (1). It arises from dysplastic oral squamous epithelium (2-6). SCC of the oral cavity attributes for 4% of malignancies in men and 2% of malignancies in women, and is responsible for 3% of all cancer deaths (7). Epidemiologic studies portray an increasing incidence of SCC in young patients worldwide especially among young females, although this malignancy is generally more common in male than in female (8). SCC may appear in endophytic, exophytic (verrucous or papillary), leukoplastic, ulcerated, erythroleukoplastic or erythroplastic forms (9,10). The most common sites of intraoral carcinoma are tongue, lip vermillion, soft palate, DOI: 10.5455/musbed.20150831012106