41 Journal of Endocrinology Research | Volume 03 | Issue 01 | January 2021 Distributed under creative commons license 4.0 DOI: https://doi.org/10.30564/jer.v3i1.2977 Journal of Endocrinology Research https://ojs.bilpublishing.com/index.php/jer ARTICLE - ed Approach to Obesity Onur Oral 1* George Nomikos 2 Nikitas Nomikos 3 1.Ege University Faculty of Sports Sciences, Department of Health Sciences and Sports, Izmir, Turkey 2.Chios Hospital, Department of Orthopaedic Surgery, Chios, Greece 3.Medical School & School of Physical Education and Sport Science, National & Kapodistrian University of Athens, Greece ARTICLE INFO ABSTRACT Article history Received: 17 March 2021 Accepted: 29 March 2021 Published Online: 31 March 2021 Obesity is a multifactorial and complex health problem that is affected by several factors including genetic, environmental, social, behavioural, and behavioural factors such as sedentary lifestyle, high-calorie nutritional intake, and the inadequate expenditure of energy are acknowledged as important aspects that cause obesity, the issue of inheritance is indisputable. The study aims to investigate the effects of inheritance on obesity and examine how understanding and detecting genetic reasons behind obesity may benefit the treatment and prevention of the obesity epidemic. The relationship between common gene variants and obesity is now being studied through the emergence of GWAS. It is undeniable that obesity is currently being studied. It may be possible to prevent and treat obesity with the detection of certain genes. Keywords: Obesity Genetics of obesity MC4R Mutation 1. Introduction Obesity is a public health concern worldwide. Obesity cases show a significant increase in both developed and developing countries. The disease is now considered an epidemic since it threatens public health in a global sense. also social and economic terms [1] . Obesity is known to be a factor that induces several other diseases such as stroke, T2D, depression, etc. Therefore, it is argued that obesity decreases average lifetime [2 3 4] . Exercise has many ben- eficial effects, leads to less telomere attrition and may diminish the risk of cancer, these two outcomes are possi- ble resulted by a reduction in oxidative stress and chronic inflammation [5] . Hippocrates was the first to recognize the need for a balanced diet and exercise and the fact that different age has different needs [6] . Hippocrates’ innova- tive spirit laid the foundations of modern medicine and the wellbeing movement: Exercise Is Medicine (EIM) ®, such as the American College of Sports Medicine (ACSM), the American Medical Association (AMA) and Harvard Medical School [7] . *Corresponding Author: Onur Oral, MD, Ph.D., Ege University Faculty of Sports Sciences, Department of Health Sciences and Sports, Izmir, Turkey; Email: onur.oral@ege.edu.tr