·Original article· Corneal aberrations in normal and keratoconic eyes using an OPD -Scan 域 Mohammad Naderan 1 , Ali Jahanrad 2 , Mahgol Farjadnia 3 1 School of Medicine, Tehran University of Medical Sciences, Tehran 1417653761, Iran 2 AJA University of Medical Sciences, Tehran 1411718541, Iran 3 School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran Correspondence to: Mohammad Naderan. School of Medicine, Tehran University of Medical Sciences, Tehran 1417653761, Iran. Moh@ Naderan. com Received: 2017-02-18 Accepted: 2018-03-12 OPD-Scan 域检测正常眼和圆锥角膜眼的角膜 像差 Mohammad Naderan 1 , Ali Jahanrad 2 , Mahgol Farjadnia 3 ( 作者单位: 1 1417653761 伊朗, 德黑兰, 德黑兰医科大学医学 院; 2 1411718541 伊朗, 德黑兰, AJA 医科大学; 3 1449614535 伊 朗,德黑兰,伊朗医科大学医学院) 通讯作者:Mohammad Naderan. Moh@ Naderan. com 摘要 目的: 评估正常眼和圆锥角膜眼的角膜高阶像差 ( HOAs)。 方法:使用 OPD-Scan 域波前像差分析仪, 评估 80 例 80 眼圆锥角膜( KC) 患者和 91 例正常眼角膜表面参数。 对 两组受试者的 Zernike 系数第三阶到第六阶, 原始彗差均 方根( RMS),彗差和总高阶像差进行比较分析。 结果:圆锥角膜眼和正常眼间测得的像差具有显著差异 (P<0. 001 ),相较于正常眼, 圆锥角膜患者像差参数显著 较高 (P<0. 001 )。 结论:通过 OPD-Scan 域测量角膜波前像差在圆锥角膜眼 中显著高于正常眼。 关键词:像差;正常眼;圆锥角膜;OPD-Scan 域;波前 引用:Naderan M, Jahanrad A, Farjadnia M. OPD-Scan 域检测正 常眼和圆锥角膜眼的角膜像差. 国际眼科杂志 2018;18(4): 599-601 Abstract 誗AIM: To evaluate higher order aberrations ( HOAs ) of the corneal surface in normal and keratoconic eyes. 誗METHODS: Using an OPD- Scan 域 wavefront analyzer, aberrometric parameters of the corneal surface in one eye of 80 patients with keratoconus ( KC) and 91 participants with normal eyes were evaluated. The Zernike coefficients from third - to sixth - order as well as root mean square ( RMS ) of primary coma, coma - like aberrations, and total HOA were calculated and compared between both groups. 誗 RESULTS: Statistically significant differences were found in all aberrometric parameters between the measurements of the KC and normal participants ( P < 0郾 001 ) . All of the aberrometric parameters were significantly higher in the KC patients compared to the normal group ( P<0. 001) . 誗 CONCLUSION: Corneal wavefront measurements by means of OPD - Scan 域 were significantly higher in keratoconic corneas than normal corneas. 誗 KEYWORDS: aberrations; healthy eyes; keratoconus; OPD- Scan 域; wavefront analysis DOI:10. 3980 / j. issn. 1672-5123. 2018. 4. 01 Citation: Naderan M, Jahanrad A, Farjadnia M. Corneal aberrations in normal and keratoconic eyes using an OPD-Scan 域. Guoji Yanke Zazhi( Int Eye Sci) 2018;18(4):599-601 INTRODUCTION K eratoconus (KC) is a usually bilateral corneal disorder, characterized by progressive corneal thinning and protrusion leading to irregular astigmatism [1-2] . The irregularity of the cornea induces corneal aberration that is among the most important factors of visual impairment in keratoconic patients [3] . The irregular astigmatism in KC patients results in increased higher order aberrations (HOAs) and subsequently vision deterioration [4-5] . Evaluation of the lower and higher order corneal aberrations has been used as a screening method to diagnose, grade the severity, and predict visual performance of KC corneas [6-7] . A significant difference in the refractive indices between air and cornea makes the anterior surface of the cornea the most influential surface in determining corneal aberration. Therefore, several studies have been conducted to evaluate the aberration induced by this surface and investigate whether these aberrations differ from those in normal eyes. Results of different studies showed that corneal aberrations of keratoconic eyes are significantly higher than these indices in normal eyes [5, 7-15] . In this study, we aimed to evaluate corneal HOAs in normal and keratoconic eyes in more detail by using an OPD - Scan 域 wavefront analyzer. SUBJECTS AND METHODS This was a prospective observational comparative study conducted at the cornea clinic of the AJA University Hospital, Tehran, Iran in 2015 and 2016. This study was in accordance 9 9 5 Int Eye Sci, Vol. 18, No. 4, Apr. 2018 http: / / ies. ijo. cn Tel:029鄄82245172 85263940 Email:IJO. 2000@163. com