Journal of Research in Medical and Dental Science 2018, Volume 6, Issue 3, Page No: 226-229 Copyright CC BY-NC-ND 4.0 Available Online at: www.jrmds.in eISSN No. 2347-2367: pISSN No. 2347-2545 Journal of Research in Medical and Dental Science | Vol. 6 | Issue 3 | May 2018 226 A Comparative Study on the Effect of Three Oil Products of Traditional Medicine: Nerium Oleander, Ginger and Chamomile on Resistance to Cold in Rats Nafiseh Hosseini Yekta 1 , Damoon Ghofrani Tabari 1 *, Mohammad Tahvilzadeh 1 , Ehsan Nassireslami 2 , Sayid Mahdi Mirghzanfari 1 1 Department of Persian Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran 2 Department of Pharmacology and Toxicology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran DOI: 10.24896/jrmds.20186335 ABSTRACT Introduction and goal: Increasing resistance to cold weather conditions is very important for military forces located in these areas, mountain climbers and people living in these areas. One of the most useful methods is to benefit from traditional medicine and the consumption of medicinal plants that are of warm quality and can improve the resistance to cold. In this research, we tried to study the effect of medicinal plants oil of Nerium Oleander, Ginger and Chamomile on the rates’ cold resistance. Materials and methods: In this research, rats were our animal model. They were divided into seven experimental groups and the effect of the oils of olive, sesame, chamomile, ginger, and oleander were studied using experimental induction of frostbite through cold water immersion method. Results: According to the results, the average times of resistance to cold are significant in the presence of oils and without oil. Among the oils used in this research, Ginger produced the highest cold resistance in rat. Conclusion: The results of this research showed that the use of oil from plants that have a warm and dry quality such as ginger can increase the resistance to cold. Key words: Traditional Medicine, Frostbite, Nerium Oleander, Ginger, Chamomile. HOW TO CITE THIS ARTICLE: Nafiseh Hosseini Yekta, Damoon Ghofrani Tabari, Mohammad Tahvilzadeh, Ehsan Nassireslami, Sayid Mahdi Mirghzanfari, A Comparative Study on the Effect of Three Oil Products of Traditional Medicine: Nerium Oleander, Ginger and Chamomile on Resistance to Cold in Rats, J Res Med Dent Sci, 2018, 6 (3): 226-229, DOI: 10.24896/jrmds.20186335 *Corresponding author: Damoon Ghofrani Tabari e-mail: d_ghofrani@yahoo.com Received: 15/01/2018 Accepted: 10/03/2018 INTRODUCTION Frostbite occurs when the tissue is exposed to cold temperature and leads to freezing of the tissue and sometimes to the tissue disability and loss. Soldiers stationed in very cold climates, mountain climbers climbing highlands, and homeless people exposed to cold weather are examples of people who may become frostbitten [1]. Exposure of the tissue or limb to very cold temperature results in vasoconstriction, decreased blood flow, and ultimately blood clotting (thrombosis) in the capillaries [2, 3]. At the cellular level, the formation of intracellular ice crystals causes changes in protein and cell wall membrane destruction [4]. When the temperature of the tissue decreases slowly, the extracellular water is crystallized and causes cell dehydration [5]. Due to this effect, intracellular electrolyte concentrations change and cause changes in the structure of the protein. Cell dehydration and capillary obstruction lead to the tissue ischemia, necrosis, severe ulcers, and loss of it [6]. Therefore, increasing the power of forces and people located in cold regions is always very important. Among the many traditional and modern methods of resistance to frostbite, the use of medicinal plants is very important in the treatment of various types of diseases [7]. It seems that some medicinal plants which are of warm quality and may increase resistance to frostbite by increasing body metabolism are an effective treatment to cope with frostbite. Among these plants are Nerium oleander, Ginger and