As-Syifaa Vol 10 (02) : Hal. 213-220, Desember 2018 ISSN : 2085-4714 213 EFEK ANALGETIK KOMBINASI EKSTRAK BUAH BELIMBING WULUH (Averrhoa bilimbi L) DAN EKSTRAK DAUN PEPAYA (Carica Papaya L.) PADA MENCIT (Mus musculus) Amran Nur Bagian Farmasi Sekolah Tinggi Ilmu Kesehatan Pelamonia Makassar Email : amrannur70@gmail.com ABSTRACT Starfruit fruit (Averrhoa bilimbi L.) and papaya (Carica papaya L.) containing the same are flavonoids which have activity as an analgesic. Flavonoids in both plants are thought to function as analgesics because they can inhibit prostrglandin synthesis which results in no release of pain meditors. The purpose of this study was to determine the analgesic effect on extract of starfruit fruit, papaya leaf extract , and a combination of both. starfruit fruit and papaya leaves macerated using 70% ethanol. Examining the analgesic activity of both extracts and combinations using a dose of 500 mg / kg BB. If the weight of the mice is 20 g/BB then the dose variation is 1 mg / 20 g BB. For the combination of the two extracts, it was made a comparison of extracts of starfruit fruit : papaya leaf extract 1: 3, 2: 2, and 1: 3. The first group was given CMC N a 0.5% as a negative control, the second group was given mefenamic acid as a positive control, the group was then given extract test solution as an extract control. After 30 minutes, 1 % acetic acid-inducing induction was given then observed mice stretching. The results showed that the fruit extract inasi komb starfruit: papaya leaf extract 1: 3 has the most excellent analgesic activity diba nding extract activity alone or in combination other. Key words: Wuluh starfruit extract (Averrhoa blimbi L), papaya leaf extract (Carica papaya L.), analgesic effect. PENDAHULUAN Bangsa Indonesia telah lama mengenal dan menggunakan tanaman yang dapat berkhasiat sebagai obat untuk menanggulangi masalah kesehatan, dan lebih dikenal dengan pengobatan tradisional. Pengetahuan tentang tanaman obat telah diterapkan berdasarkan pengalaman dan keterampilan yang secara turun temurun diwariskan dari satu generasi ke generasi berikutnya. Meskipun sistem pengobatan di Indonesia sudah berkembang, pemanfaatan tanaman obat untuk pengobatan dan perawatan masih cukup tinggi. Berdasarkan Survey Sosial Ekonomi Nasional tahun 2001, tercatat 57,7% penduduk Indonesia melakukan pengobatan sendiri tanpa bantuan medis, 31,7% diantaranya menggunakan tumbuhan obat tradisional, dan 9,8% memilih