Journal of Neuroradiology (2011) 38, 141—147
ORIGINAL ARTICLE
Look for the nerves! MR neurography adds essential
diagnostic value to routine MRI in pediatric practice:
A pictorial overview
Cherchez les nerfs ! La neurographie RM apporte des arguments
diagnostiques essentiels à l’IRM de routine en pratique pédiatrique :
une revue iconographique
Laura Merlini
a,*
, Maria I. Vargas
b
, Mehrak Anooshiravani
a
,
Magalie Viallon
b
, Joel Fluss
c
, Sylviane Hanquinet
a
a
Unit of Pediatric Radiology, Geneva University Hospital HUG, 6, Willy-Donzé, 1205 Geneva, Switzerland
b
Unit of Neuroradiology, University Hospital of Geneva, 1205 Geneva, Switzerland
c
Unit Pediatric Neurology, University Hospital of Geneva, 1205 Geneva, Switzerland
Available online 12 January 2011
KEYWORDS
MR neurography;
Children;
Peripheral nerves;
Diffusion tensor
imaging
Summary
Purpose. — This study aimed to assess the feasibility of magnetic resonance (MR) neurography
in children, and the potential roles of diffusion-weighted imaging (DWI) and fiber-tracking (FT)
techniques.
Methods. — Five pediatric patients (age range: 6—12 years) underwent magnetic resonance
imaging (MRI) for various clinical indications: neurogenic bladder (case 1); persistent hand
pain following minor trauma (case 2); progressive atrophy of the lower left extremity muscles
(case 3); bilateral hip pain (case 4); and palpable left supraclavicular mass (case 5). All studies
were performed using a 1.5-T Avanto MRI scanner (Siemens, Erlangen, Germany). The protocol
included 3D T2-weighted STIR and SPACE imaging, T1-weighted fat-saturation post-gadolinium
imaging and diffusion tensor imaging (DTI) with tractography. ADC (N × 10
-3
mm
2
/s) and FA val-
ues were calculated from regions of interest (ROIs) centered on the nerves. Nerve-fiber tracks
were calculated using a fourth-order Runge-Kutta algorithm (NeuroD software).
Results. — MR neurography allowed satisfactory visualization of all neural structures, and FA
and ADC measurements were feasible. The final diagnoses were Tarlov cysts, median-nerve
compression, sciatic perineurioma, Charcot-Marie-Tooth disease and plexiform neurofibroma in
a patient with NF-1.
∗
Corresponding author. Tel.: +41 22 37 27 020; fax: +41 22 37 27 080.
E-mail address: Laura.Merlini@hcuge.ch (L. Merlini).
0150-9861/$ – see front matter © 2010 Elsevier Masson SAS. All rights reserved.
doi:10.1016/j.neurad.2010.09.006
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