Int J Cur Res Rev | Vol 12 • Issue 18 • September 2020 25 Corresponding Author: Navin Kumar, PhD, Professor, Department of Biotechnology, Graphic Era (Deemed to be University), 566/6, Bell Road, Clement Town, Dehradun, Uttarakhand, PIN-248002, India; Contact: +91-7417325585; +91-135-2642799 (217); Email: navinbajpai@gmail.com; navinkumar.bt@geu.ac.in ISSN: 2231-2196 (Print) ISSN: 0975-5241 (Online) Received: 15.06.2020 Revised: 21.07.2020 Accepted: 25.08.2020 Published: 22.09.2020 Review Article International Journal of Current Research and Review DOI: http://dx.doi.org/10.31782/IJCRR.2020.12186 IJCRR Section: Healthcare Sci. Journal Impact Factor: 6.1 (2018) ICV: 90.90 (2018) INTRODUCTION Fungi are considered to be one of the potential health hazards to animals including humans. Annually, fungal diseases are responsible for over 1.5 million deaths and infecting over a billion people worldwide. Candida, Cryptococcus, Pneumo- cystisand Aspergillus are the main fungal genera responsible for such infections 1 . The occurrence of life-threatening fun- gal infections has increased in immune-compromised AIDS patients, blood cancer, neonates, and organ transplants 2,3 . Fungal infections present a possible danger to health world- wide owing to their elevated mortality and morbidity rate 4 . Mortality associated with the fungal disease is similar to that of tuberculosis (more than 1.6 million) and above 3-fold more than malaria 1 . Candida is a well-known group of fungi containing around 20 pathogenic species. It is a member of the Saccharomy- cetes class, the Saccharomycetales order, and the Saccha- romycetaceae family. Ubiquitous, opportunistic, dimorphic, and commensal fungi are representatives of this group. The natural flora of the gastrointestinal tract, the mucosal oral cavity, and the human reproductive organs comprises of vari- ous species of Candida 5 . Candidiasis is a condition of Candida infection which caus- es shallow mucocutaneous infections, invasive tissue, and bloodstream infections 6,7 . C. albicans, the most common pathogenic species, is followed by C. tropicalis, C. glabrata, and C. parapsilosis 8 . Clinical isolates have been reported to be resistant to existing antifungals, particularly azoles, echi- nocandins, and polyene 9 . Hydrophobicity of the cell surface, hyphal transformation hydrolytic enzyme secretion and de- velopment of biofilm over abiotic and biotic surfaces are well established primary virulence features of the Candida 10,11 . Most important features of Candida spp. are the ability to form a biofilm, a three-dimensional multicellular structure mainly composed of proteins, carbohydrates, phosphorus, hexosamine, and, uronic acid. Biofilm facilitates adhesion and maturation on the biotic and abiotic surfaces, ranging from the mineral surface and mammalian tissues to synthetic polymers and indwelling medical gadgets, resulting in drug . ABSTRACT Fungal infections are drawing attention because of the high mortality and morbidity rate associated with them. Candida, Crypto- coccus, Pneumocystis, and Aspergillus are the main members of fungal genera responsible for life-threatening fungal infections all over the world. Candida exists as commensal opportunistic pathogens in the natural flora of human beings. Members of this genus have specialized virulence attributes which include adhesion, biofilm formation, yeast to hyphal transition, cell surface hydrophobicity, and secretion of hydrolytic enzymes. C. albicans, C. parapsilosis, C. glabrata, and C. tropicalis are key species, mainly responsible for 95% of candidiasis worldwide. Azoles, amphotericin B, echinocandins and terbinafine are the main syn- thetic drugs against the pathogens. Rising resistance to antifungals demands the development of alternative drugs, especially of plant origin. In this review, we have included the selected plants having significant anti-Candida potential, based upon recent studies. Key Words: Candida, Candidiasis, Biofilm, Anti-Candida, Phytoactive, Synthetic drugs, MIC, Camellia sinensis, Hypericum hav- vae. A Recent Report on ‘Plants with Anti-Candida Properties’ Darshan Kumar 1 , Ayesha 2 , Madhulika Jha 3 , Pankaj Gautam 4 , Himanshu Joshi 5 , Navin Kumar 6 1,2,3,6 Department of Biotechnology, Graphic Era Deemed to be University, 566/6, Bell Road, Clement Town, Dehradun, Uttarakhand, India; 4 Department of Life Sciences, Graphic Era Deemed to be University, 566/6, Bell Road, Clement Town, Dehradun, Uttarakhand, India; 5 College of Pharmacy, Graphic Era Hill University, Bhimtal Campus, Uttarakhand, India. Copyright@IJCRR