www.wjpps.com │ Vol 11, Issue 6, 2022. │ ISO 9001:2015 Certified Journal │ 1626 Lobo et al. World Journal of Pharmacy and Pharmaceutical Sciences A STUDY ON ANTI-DEPRESSANT ACTIVITY OF ESSENTIAL OIL OF CUPRESSUS SEMPERVIRENS IN EXPERIMENTAL MICE Josline Ancita Lobo*, Satish S. Bhagyashree Ganesh Patgar and A. R. Shabaraya Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Post Farangipete, Mangalore - 574143, Karnataka, India. ABSTRACT The objective of the proposed study was to evaluate the anti-depressant effect of essential oil Cupressus sempervirens (EOCS) in experimental animal models. Anti-depressant activity of essential oil Cupressus sempervirens was investigated in experimental animal models. Two doses of EOCS (75mg/kg and 150mg/kg) (P.O) was subjected for the evaluation. Imipramine (10mg/kg) (P.O) was used as standard in all the Forced swim test (FST) model of animals and parameters estimated includes duration of immobility and estimation of biochemical mono amino oxidase. Both the lower dose (75mg/kg) and higher dose (150mg/kg) of the essential oil Cupressus sempervirens showed dose depended significant decrease in depression and decrease in biochemical parameter of Mono Amino Oxidase when compared with the vehicle control. The result obtained was comparable with that of the standard drug Imipramine. The finding of the present study provides the evidence that the essential oil Cupressus sempervirens may be beneficial against the depression. KEYWORDS: Anti-depressant activity, Cupressus sempervirens, Imipramine, Mono amino oxidase. INTRODUCTION Depression is included in mood disorders. Mood disorder is a collection of clinical conditions characterized by loss of feeling and individual experience severe suffering. Depressed patients feel a loss of energy and interest, feelings of guilt, difficulty in concentrating, changes in appetite, and thoughts of death or suicide. [1] This disease has affected a high proportion of the world’s population and people of different ages, preventing them from good WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 7.632 Volume 11, Issue 6, 1626-1633 Research Article ISSN 2278 – 4357 *Corresponding Author Josline Ancita Lobo Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Post Farangipete, Mangalore - 574143, Karnataka, India. Article Received on 05 April 2022, Revised on 25 April 2022, Accepted on 15 May 2022 DOI: 10.20959/wjpps20226-22268