International Journal of Medical Science and Current Research (IJMSCR) Available online at: www.ijmscr.com Volume3, Issue 4, Page No: 451-454 July-August 2020 International Journal of Medical Science and Current Research | July-August 2020 | Vol 3 | Issue 4 451 ISSN (Print): 2209-2870 ISSN (Online): 2209-2862 (International Print/Online Journal) SJIF IMPACT FACTOR: 5.565 PUBMED-National Library of Medicine ID-101739732 A Study on Serum Liver Enzyme and Serum Lipid Profile in Alcoholic and Non Alcoholic controls: A case control study Divya Tripathi 1 , Mohmmad Amil Rahman 2 1,2 Department of Medical Biochemistry, National Institute of Medical Sciences & Research, NIMS University Rajasthan, Jaipur *Corresponding Author: Mohmmad Amil Rahman Department of Medical Biochemistry, National Institute of Medical Sciences & Research, NIMS University Rajasthan, Jaipur Type of Publication: Original Research Paper Conflicts of Interest: Nil ABSTRACT Background: Alcohol has many effects on lipid metabolism, including inducing de novo fatty acid synthesis and inhibiting fatty acid oxidation in the liver. The most common effect of alcohol is to increase plasma triglyceride levels. The coronary heart disease has been reported to decrease with moderate drinking in both sexes, but such benefit disappears with high consumption. Heavy alcohol consumption for prolonged periods result in marked perturbation of the lipid transport system, reflecting both effects of alcohol on lipid metabolism in hepatic and extra hepatic tissue, as well as its marked various bad effects on liver function. This present study was undertaken to compare lipid profiles in alcoholics and non-alcoholics patients attending tertiary care center. Material and Methods: Present study was comparative, observational case control study. Among selected 180 patients, from age group 18-50 years of age, 90 were alcoholic and 90 who did not consume alcohol or do not have history of alcohol consumption were included in the study. Results: We analyzed Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline Phosphatase(ALP), Total Cholesterol, HDL, Triglyceride, LDL and VLDL values from 180 subjects, from age group 18-50 years. Among them 90 were alcoholic and 90 were non-alcoholic. Overall mild raised ALT, AST, ALP and total cholesterol, serum triglyceride; VLDL, LDL values and lowered HDL were noted in alcoholic group as compared to non-alcoholic group. Highly statistically significant values were noted in HDL, LDL, TC, TG and Liver enzymes (AST, ALT & ALP) values. Conclusion: As we were analyzed the liver enzyme and lipid profile and we found they all were significant in alcoholic group as their levels they tend to be dyslipidemia, cardiac stroke, myocardial infarction and liver disorders. Chronic alcoholism for human health is work like a silent killer and a person will leads to cardiac as well as liver disorders. Keywords: Alcohol, Liver Enzyme, Lipid Profile, Cardiovascular risk, Dyslipidemia and Chronic Alcoholism. INTRODUCTION The National Mental Health Survey of India 2015–16 found the prevalence of AUDs to be 9% in adult men. In India, the alcohol-attributable fraction (AAF) of all cause deaths was found to be 5.4%. Around 62.9% of all the deaths due to liver cirrhosis were attributable to alcohol use [1] . Liver plays crucial role in our body it activates various enzymes and also promotes a numerous exocrine and endocrine metabolic activities. As the liver is involved in many steps of lipid metabolism and transport, therefore chronic liver disease can affect plasma lipid levels in a variety of ways. Nowadays alcoholic liver disease is a prime cause of morbidity and mortality throughout the world. Alcohol consumption causes fatty liver,