Current Psychopharmacology Rashmi S. Pal 1,* , Nikita Saraswat 1 , Pranay Wal 1 , Ankita Wal 1 , Yogendra Pal 1 and Tamsheel F. Roohi 1 1 Department of Pharmacy, PSIT, Kanpur, India Abstract: Background: Depression is the neuropsychiatric disorder that can lead to the disruption of brain nerves by elevating different mechanisms and neurotransmitters such as serotonin, noradrenaline, dopamine. It can have a series of episodic events that can cross one episodic depression to another and manifest various symptoms such as agitation, mel- ancholia, deep sadness, psychomotor retardation, mood swings and suicidal deaths. Objective: This paper gives information about the various factors such as psychological, genetic, biological and environmental factors that play a vital role in the pathogenesis of depression and its associated symptoms. In spite of usage of antidepressant drugs, many clinicians and physicians follow other therapies and interventions or certain medications such as psychological studies, cognitive sciences, and meditation and yoga that help in the ailment of depression. Methods: The data was collected by studying combination of research and review papers from different databases like PubMed, Medline, and Web of science by using search key- words like “depression”, “cognitive sciences”, “meditation”, “yoga”, “psychotherapies”, “mindfulness activities”, “factors associated with depression and its episodes”. Result: It was found that besides the use of antidepressants, a considerable number of stud- ies and researches on therapies exhibit the examined effects of different psychotherapies, psychological studies, cognitive sciences and yoga-based interventions show potential ef- fects in the ailments of depression and its associated symptoms. Conclusion: Based on this paper, we have concluded that with the use of psychotherapies such as interpersonal therapy, problem-solving therapy, MBCT, MBSR, DBT, ACT, yoga and its different techniques are more effective than other medication therapies. A R T I C L E H I S T O R Y Received: August 02, 2019 Revised: September 13, 2019 Accepted: October 02, 2019 DOI: 10.2174/2211556008666191019142247 Keywords: Cognitive sciences, depression, mindfulness activities, psychological factors, psychological studies, treatment, yoga. 1. INTRODUCTION According to the World Health Organization (WHO), depression (neuropsychiatric disorder) is the second-largest disease after heart diseases among the population in the last few decades in *Address correspondence to this author at the Department of Pharmacy, PSIT, Kanpur, India; Tel: 9129826459; E-mail: rashmisaxenapal@gmail.com the whole world. Out of every 12 humans either male or female, about 1 female and 5-6 males suf- fer from depression. Depression is not only a dis- order of adult but it can also affect the 5% teenag- ers 10-19 age groups and about 2-3% of children, reasons were either not known or psychiatric dis- orders [1, 2]. Depression is the most appropriate reason for all neuropsychological disorder. Most of the people believe that depression is some kind of mythological problem because it is related to 2211-5579/19 $58.00+.00 © 2019 Bentham Science Publishers Send Orders for Reprints to reprints@benthamscience.net Current Psychopharmacology, 2019, 8, 177-193 177 REVIEW ARTICLE An Insight on the Association of Psychological Studies, Cognitive Sciences and Meditation in Treating Depression