217 © Springer International Publishing AG 2017 J.L. Mehta et al. (eds.), Biochemical Basis and Therapeutic Implications of Angiogenesis, Advances in Biochemistry in Health and Disease 6, DOI 10.1007/978-3-319-61115-0_10 Chapter 10 The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior Ramon Andrade De Mello, Michael Luis, António Araújo, Rui Manuel Reis, and Venceslau Hespanhol R.A. De Mello, MD, PhD (*) Department of Medical Oncology, Clatterbridge Health Park, Clatterbridge Road, Birkenhead, Wirral CH63 4JY, UK Department of Medical Oncology, Clatterbridge Cancer Centre, Wirral, Warrington & Liverpool, UK Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal Division of Medical Oncology, São Paulo Medical School, Federal University of São Paulo (EMP - UNIFESP), São Paulo, Brazil Service of Pneumology, Hospital São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal e-mail: ramondemello@doctors.org.uk M. Luis Department of Medical Oncology, Centro Hospitalar de Trás-os-Montes e Alto Doutor, Vila Real, Portugal A. Araújo Department of Medical Oncology, Centro Hospitalar do Porto, Porto, Portugal R.M. Reis Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal V. Hespanhol Service of Pneumology, Hospital São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal Abstract Currently, lung cancer is the leading cause of cancer-related death in western nations. Risk factors are usually associated with tobacco consumption, occupational exposure, radon and passive smoking. To date, many factors infuence