AGA Abstracts * Celiac Disease Compared to Controls ** PWAGs Compared to Controls Mo1027 PATTERNS OF MARIJUANA USE AMONG CELIAC DISEASE PATIENTS: A POPULATION BASED ANALYSIS OF THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES) Rita M. Abdelmessih, Haley M. Zylberberg, Daniela Jodorkovsky, Peter H. Green, Benjamin Lebwohl Background: Marijuana use has been assessed in patients with IBD and functional bowel disorders and may contribute to symptoms in some patients. However, use in those with celiac disease (CD) has not been assessed. Our aim was to evaluate patterns of marijuana use in a large population-based survey among patients with CD, as well as, people who avoid gluten (PWAG) and controls. Methods: We analyzed data from the National Health and Nutrition Examination Survey (NHANES), and included respondents spanning the years 2009-2014. All patients who answered questions regarding CD and drug use as part of the interview and underwent laboratory evaluation for the diagnosis of CD were included, which consisted of 22,278 participants. Participants were classified into three categories: diagnosed CD (based on questionnaire response), undiagnosed CD (based on serologic presence of tissue transglutaminase and endomysial antibodies), and PWAG (based on questionnaire response). We used the chi square test and multivariable logistic regression to compare participants with CD and PWAGs to controls regarding the use of marijuana. Results: 10,193 were included in the analysis (12,083 excluded: age <18, did not answer the necessary questions in the marijuana survey, i.e. those who answered "refused" or "don't know"), 55 patients with CD (9 diagnosed, 46 undiagnosed and with serologic evidence of CD), 122 PWAGs and 10,016 controls; these were subsequently weighted for the analysis. Routine marijuana use (defined as monthly use of marijuana) was reported by 46% of controls, compared to 6% of participants with diagnosed CD (P=0.005), 66% undiagnosed CD (P= 0.098) and 51% of PWAGs (P=0.536) (Table 1). However, subjects with diagnosed CD were found to have lower odds of routine marijuana use compared to controls, even after controlling for age, sex, ethnicity and health insurance status (OR=0.12, 95% CI: 0.01-0.94; P=0.043) (Table 2). Among users of marijuana, there were no differences between frequency of marijuana use between participants with CD, PWAGs and controls. PWAGS were also less likely to report frequent marijuana use (>2x a week) than controls (22% vs. 55%, p= 0.0071). Conclusion: This study is the first to evaluate marijuana patterns in a large-scale population based survey among CD patients and PWAGs. In all groups marijuana use was surprisingly high. Although there were no differences among subjects with CD, PWAGs and controls who have ever used marijuana, subjects with diagnosed CD appear to have signifi- cantly decreased routine use of marijuana when compared to controls and PWAGs, after adjusting for age, gender, ethnicity and health insurance status. PWAGs appear to have less frequent marijuana use when compared to controls. Future research should focus on the utilization of marijuana as it may contribute to further understanding of symptoms and treat- ments. S-676 AGA Abstracts Mo1028 PREVALENCE OF COLORECTAL ADENOMAS AMONG RECENTLY- DIAGNOSED ADULT CELIAC DISEASE PATIENTS Juan S. Lasa, Astrid Rausch, Luis Florez Bracho, Diego Berardi, Ignacio Zubiaurre BACKGROUND: Celiac disease has been associated to an increased risk of certain tumours, such as small intestine adenocarcinoma or lymphoproliferative disorders. The association between celiac disease and colorectal neoplasia has been studied, but results contemplate adult celiac patients under treatment. Hence, the question of whether recently-diagnosed celiac disease patients could increase the risk of colorectal adenomas has not been assessed. AIM: To compare the prevalence of colorectal adenomas between adult patients with recent diagnosis of celiac disease who were not on a long-term gluten-free diet at the moment of colonoscopy versus healthy controls who undertook screening colonoscopy. MATERIALS AND METHODS: A retrospective case control study was undertaken. Patients with a diagnosis of celiac disease at an age of 45 years or more who undertook colonoscopy six months before or six months after the initiation of a gluten-free diet were enrolled as cases. Asymptom- atic subjects undertaking screening colonoscopy were recruited as controls in a 2:1 fashion. The prevalence of colorectal adenomas, as well as their location and the prevalence of advanced adenomas were compared between groups. Colorectal neoplasia risk factors were also compared between groups: familiar history of colorectal cancer, obesity, tabaquism. A univariate analysis was performed with Odds Ratio estimations with their 95% confidence intervals and a multivariate analysis was performed to evaluate independent variables signifi- cantly associated with both adenoma and advanced adenoma prevalence. RESULTS: From January 2008 to March 2017, 49 adult patients with a recent diagnosis of celiac disease as well as 118 controls were identified and enrolled for analysis. There was a greater prevalence of female patients among the celiac group (p 0.001), with no significant differences in terms of age and cecal intubation rate or bowel preparation quality. There were more obese patients among control patients (21.19 vs 2.08%, p= 0.02), and a higher proportion of tabaquism was found among celiac patients (21.25 vs 15.38%, p=0.02). There was a non-significant difference in terms of adenoma prevalence between celiac patients and controls (41.67 vs 27.97%, p=0.08): when analyzing their prevalence according to their location, we found no difference in terms of right colon adenoma prevalence; however, celiac disease patients showed a significantly higher prevalence of left-colon adenomas (35.42 vs 17.8%, p=0.01). No significant differences were found in terms of the prevalence of advanced adenomas. On multivariate analysis, recently-diagnosed celiac disease and age were significantly associ- ated with an increased adenoma prevalence. CONCLUSION: Adults with a recent diagnosis of celiac disease have an increased prevalence of colorectal adenomas, which are located predominantly in the left colon. Mo1029 INFLAMMATORY BIOMARKERS AS PREDICTORS OF MUCOSAL HEALING IN PATIENTS WITH CELIAC DISEASE Rita M. Abdelmessih, Srihari Mahadev, Peter H. Green, Benjamin Lebwohl Introduction: In patients with celiac disease (CD) normalization of anti-gliadin and transglu- taminase antibodies may occur despite persistent small bowel mucosal inflammation and villous atrophy that may only be determined histologically. Given the association of persistent villous atrophy with subsequent morbidity, identification of this abnormality can serve to risk-stratify patients. We aimed to study if the inflammatory biomarkers, Neturophil- Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR) and C-reactive protein (C-RP) predict small bowel mucosal healing on follow-up biopsies in CD. Methods: We performed