Copyright@ Prisca Nsimba Mayamba | Biomed J Sci & Tech Res| BJSTR. MS.ID.003155. 13589 Research Article ISSN: 2574 -1241 Effectiveness of Injectable Artesunate Versus Quinine in The Treatment of Severe Malaria in Children Aged 0-59 Months in Kenge, DRC Prisca Nsimba Mayamba 1 *, Joel Kafumbi Katsiatsia 1 , Cush Ngonzo Luwesi 2 , Jean-Jacques Kisaka Ngimbi 1,3 and Gertrude Lundu Yenamawu 1 1 Assistant Higher Institute of Medical Techniques Mary Queen of Peace Kenge (ISTM-MRP), Kenge, DRC 2 Associate Professor, Faculty of Economics, University Kwango (UNIK), Kenge, DRC 3Executive Secretary, Civil Society Health Kwango, Kenge, DRC *Corresponding author: Prisca Nsimba Mayamba, Assistant Higher Institute of Medical Techniques Mary Queen of Peace Kenge (ISTM-MRP), Kenge, DRC DOI: 10.26717/BJSTR.2019.18.003155 Received: May 20, 2019 Published: May 29, 2019 Citation: Prisca Nsimba M, Joel Kafumbi K1, Cush Ngonzo L, Jean-Jacques Kisaka N, Gertrude Lundu Y. Effectiveness of Injectable Artesunate Versus Quinine in The Treatment of Severe Malaria in Chil- dren Aged 0-59 Months in Kenge, DRC. Biomed J Sci & Tech Res 18(3)-2019. BJSTR. MS.ID.003155. ARTICLE INFO abstract Malaria Threatens globally the lives of 3.3 trillion people living in 109 countries. This study compares the effectiveness avocation to of the drug artesunate versus quinine That of in the treatment of severe malaria Among the children of less than 59 months. For That reason, a survey and quantitative cross-sectional analysis has documentary Were Conducted one year based design to suit les explanatory correlation has entre les drugs and the rate of malaria treatment. A sample size of 380 children Was selected from the City of Kenge, half of Whom Were Treated with artesunate (190 children) and the other half with quinine (190 children). Results indicate indication at 5% significance level That 59% of patients Treated with artesunate drug Had a drop in temperature During the first day of treatment contre 49.5% Treated with drug quinine. The cure rate Was Observed 88. 9% for the artesunate group versus 83.7% for the quinine group. The death rate Was Established at 7.9% for the quinine group contre 1.1% for the artesunate group. Finally, a correlation Was Established entre les kind of treatment, parasitaemia at the start of the treatment, the adjuvant treatment, the Evolution of clinical signs During treatment, the final assessment, and the treatment effectiveness. Hence, the artesunate Was found to be more effective than quinine in Treating severe malaria. the final assessment, and the treatment effectiveness. Hence, the artesunate Was found to be more effective than quinine in Treating severe malaria. the final assessment, and the treatment effectiveness. Hence, the artesunate Was found to be more effective than quinine in Treating severe malaria. Summary Malaria threatens 3.3 billion people in 109 countries in the world. This study aimed to compare the effectiveness of artesunate versus quinine in the treatment of severe malaria in children aged 0-59 months. We conducted a cross-quantitative investigation; correlational explanatory quote based on the literature review. A sample of 380 children was selected in the City of Kenge, of which 190 treated with artesunate and half treated with quinine. The results indicate a 5% significance level of 59% of patients treated with artesunate experienced a temperature drop on the first day against 49.5% treated with quinine. Moreover, the cure rate was 88.9% observed in the group of artesunate against 83.7% in the group of quinine. The death rate it was 7.9% in the group of quinine against 1.1% in the group of artesunate. Finally, interdependence were established between the established treatment parasitaemia at the beginning of treatment, adjuvant treatment, the evolution of clinical symptoms during treatment, the final evaluation and treatment efficacy. In conclusion, artesunate was more effective than quinine on the treatment of severe malaria or severe malaria.