Please cite this article in press as: Moreddu E, et al. Incidence of salivary side effects after radioiodine treatment using a new specifically- designed questionnaire. Br J Oral Maxillofac Surg (2017), http://dx.doi.org/10.1016/j.bjoms.2017.03.019 ARTICLE IN PRESS YBJOM-5154; No. of Pages 4 British Journal of Oral and Maxillofacial Surgery xxx (2017) xxx–xxx Available online at www.sciencedirect.com ScienceDirect Incidence of salivary side effects after radioiodine treatment using a new specifically-designed questionnaire E. Moreddu a,∗ , K. Baumstarck-Barrau b , S. Gabriel c , N. Fakhry d , F. Sebag e , O. Mundler c , C. Chossegros a , D. Taïeb c a Department of Maxillofacial Surgery, la Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, 13005 Marseille, France b Unité d’Aide Méthodologique à la Recherche Clinique et Épidémiologique, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France c Department of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, European Center of Research in Medical Imaging (CERIMED), 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France d Department of Otorhinolaryngology and Cervico-Facial Surgery, la Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, 13005 Marseille, France e Department of Endocrine Surgery, la Timone University Hospital, Aix-Marseille University, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France Accepted 28 March 2017 Abstract Sialadenitis is one of the common complications of radioiodine treatment for thyroid malignancy. The aim of this study was to evaluate the prevalence of radioiodine-induced sialadenitis and other side effects by using a self-administered questionnaire. From 1 January 2011 to 31 December 2012 all consecutive patients with a newly-established diagnosis of thyroid cancer who were treated with adjuvant radioiodine at La Timone University Hospital were sent a self-administered questionnaire on salivary complaints that had been specifically designed for this study. A total of 413 patients sent the questionnaire back, of whom 100 (24%) had experienced pain, 116 (28%) discomfort or swelling, and 147 (36%) dry mouth or xerostomia. This survey has highlighted the number of side effects of radioiodine treatment in a large group of patients and corroborates previous observations. Our new self-administered questionnaire may be useful to others for follow-up and research. © 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. Keywords: thyroid neoplasm; recombinant Human TSH; radioiodine; sialadenitis; salivary Introduction Radioiodine (I 131 ) is a widely used adjuvant treatment for differentiated thyroid cancer. Overall it is safe, with few complications. Damage to the salivary glands is a specific side effect that may have a serious impact on the patient’s quality of life, and sialadenitis is the most common reported adverse effect. 1–3 It usually occurs within the first 24 hours of the radioiodine being given, 1,2,4 but may also occur ∗ Corresponding author. Tel.: +33 4 91 38 58 48, fax: +33 4 91 38 56 34. E-mail address: eric.moreddu@ap-hm.fr (E. Moreddu). later and lead to long-term complications such as painful swelling, dry mouth, and xerostomia, as well as related com- plications such as caries and candidiasis. 3,5–8 Histological alterations induced by radiation mainly affect the parotid glands because of their large proportion of serous tissue (duc- tal cells) that absorbs iodine to higher concentrations than the mucous tissue of the submandibular glands. 5 There is still conflicting evidence about the efficacy of interventions to pre- vent radiation-induced salivary dysfunction by using lemon juice, 4,9,10 massage, or treatments. Despite these interven- tions, modifications of salivary function by radioiodine still happen. 7,11–19 http://dx.doi.org/10.1016/j.bjoms.2017.03.019 0266-4356/© 2017 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.