Can Cognitive-Behavioral Therapy Be Optimized With Parent Psychoeducation? A Randomized Effectiveness Trial of Adolescents With Major Depression in Puerto Rico GUILLERMO BERNAL* CARMEN L. RIVERA-MEDINA* ,1 EDUARDO CUMBA-AVIL  ES* MAE LYNN REYES-RODR  IGUEZ † EMILY S  AEZ-SANTIAGO* YOVANSKA DUART  E-V  ELEZ* ,2 LELIS NAZARIO ‡ NATALIE RODR  IGUEZ-QUINTANA* JEANNETTE ROSSELL  O* This is a longitudinal randomized control trial on the impact of adding a parent psychoeducation intervention (TEPSI) as part of cognitive-behavioral therapy (CBT) for adolescents with Major Depressive Disorder (MDD) in a Puerto Rican sample. We tested * Bernal, Professor of Psychology (retired); Rivera-Medina, Assistant Professor in Research; Cumba- Avil es, Assistant Research Professor; S aez-Santiago, Psychoeducation Co-leader; Rodr  ıguez-Quintana, Research Assistant; Rossell o, Profesor of Psychology (Retired), Institute for Psychological Research (IPsi), University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico. † Reyes-Rodr  ıguez, Psychoeducation Co-leader, Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC. ‡ Nazario, Professor of Psychiatry, Department of Psychiatry, University of Puerto Rico Medical Sciences Cam- pus, San Juan, Puerto Rico. 1 Department of Psychology, University of Puerto Rico Rio Piedras Campus, San Juan, Puerto Rico. 2 Duart e-V elez, Assistant Profesor of Research, Department of Psychiatry and Human Behavior, Brown Univer- sity, Providence, RI, 02912. Correspondence concerning this article should be addressed to Guillermo Bernal, Institute for Psycho- logical Research (IPsi), University of Puerto Rico, Rio Piedras Campus, 273 Uruguay Avenue, Suite 6F, Centrum Plaza, San Juan, PR 00917-2214. E-mail: guillermobernal@icloud.com This study was supported by NIH Research Grant R01-MH67893 and by a Research Supplement to Pro- mote Diversity in Health-Related Research Grant 3R01-MH067893-034S funded by the National Institute on Mental Health, Division of Services and Intervention Research, Mental Disorders, Child and Adoles- cent Treatment and Preventive Intervention Research Branch. The content is solely the responsibility of the authors and does not represent the official views of the NIMH or the National Institute of Health. Sup- port was also received from the Institutional Funds for Research from the Dean of Graduate Studies and Research at the University of Puerto Rico, R  ıo Piedras. The authors are grateful to Jos e Noel Caraballo, Ph.D., Terry Duncan, Ph.D. (Statistical consultants); Mar  ıa I. Jim enez, Ph.D., Frances Centeno, Ph.D., Mar  ıa T. Rivera, Ph.D., Julia Gonz alez, Ph.D., Yaritza M. Lopez, Ph.D., Karen Bonilla, Ph.D., Elisabeth Avil es, Ph.D. (Treatment team), Vidalina Feliciano, Ph.D., Caroline Forastieri, Ph.D., Jessica Rodr  ıguez, Patricia Garcia, Ph.D., Karinnette Rivera, Ph.D., Shirleen M. Collazo, Ph.D., Veronica Velez (Evaluation Team), Michelle Osuna, Ph.D., Amarilis Galloza, Samia Ortiz, and Yolanda Cruz, B.A. (Other support team). Also, the support of the administrative and secretarial staff (Carmen Rios Reyes, Ada Rivera Pagan, Wilmarie Santiago, Liz Bultron, & Fermarie Villegas) at the Institute for Psychological Research at UPR-RP was invaluable. I am also thankful to Cristina Adames, my research assistant who provided important support in the final stages of the manuscript. Most importantly we are grateful to the adoles- cents and parents who participated in the study. 1 Family Process, Vol. x, No. x, 2019 © 2019 Family Process Institute doi: 10.1111/famp.12455