946 Chin J Integr Med 2012 Dec;18(12):946-954 Triphala (in Sanskrit, "tri" means three, and "phala" means fruits), composed of the three medicinal myrobalans Terminalia chebula Retz. ( Haritaki , Family: Combretaceae), Terminalia bellirica Roxb. ( Bibhitaki , Family: Combretaceae) and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. ( Amalaki or the Indian gooseberry, Family: Euphorbiaceae) is an important drug in the traditional Indian system of medicine the Ayurveda (Figure 1). (1-5) It is an antioxidant rich herbal formulation and has been described by certain Ayurvedic practitioners as an effective Rasayana (rejuvenator) drug. (1-5) The myriad beneficial effects of Triphala are supposed to be due to the combination of the three fruits. The drug characteristics and uses of each of these plants in Ayurveda are listed in Table 1. Depending on the medical condition Triphala is used in various forms like as churna (fine powder), kwatha (decoction), mashi (ash), taila (oil) and gritha (Triphala cooked with clarified butter or Ghee). (1) Their mode of preparation, composition and medicinal uses are specified in Table 2. TRADITIONAL USES of TRIPHALA In Ayurveda, Triphala is a frontline remedy for treating various gastrointestinal ailments and a universal panacea against various diseases and ailments. Triphala is widely used to treat constipation, as an intestinal cleanser, as a gastrointestinal tract tonifier, to fasten peristalsis and to support both REVIEW Scientific Validation of the Ethnomedicinal Properties of the Ayurvedic Drug Triphala: A Review Manjeshwar Shrinath Baliga 1 , Sharake Meera 2 , Benson Mathai 3 , Manoj Ponadka Rai 1 , Vikas Pawar 4 , and Princy Louis Palatty 5 ©The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2012 1. Department of Research and Development, Father Muller Medical College, Kankanady, Mangalore, Karnataka (575002), India; 2. Sanjeevini Ayurvedic Chikitsalaya, Mallikatte, Mangalore, Karnataka (575003), India; 3. Department of Pharmacology, St. John's Pharmacy College, Vijayanagar II Stage, Bangalore, Karnataka (560040), India; 4. Unilever R&D, No. 64, Main Road, Whitefield, Bangalore, Karnataka (560066), India; 5. Department of Pharmacology, Father Muller Medical College, Kankanady, Mangalore, Karnataka (575002), India Correspondence to: Dr. Manjeshwar Shrinath Baliga, Tel: 91-824-2238331, Fax: 91-824-2437402/91-824-2436352, Email: msbaliga@gmail.com DOI: 10.1007/s11655-012-1299-x ABSTRACT Triphala, a herbal formula composed of the three fruits of Terminalia chebula Retz. ( Haritaki , Family: Combretaceae), Terminalia bellirica Roxb. ( Bibhitaki , Family: Combretaceae) and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. ( Amalaki or the Indian gooseberry, Family: Euphorbiaceae) is considered to be a universal panacea in the traditional Indian system of medicine the Ayurveda. It has been described in the Ayurveda text as a " Rasayana " and to rejuvenat the debilitated organs. Ayurvedic physicians use Triphala for many ailments but most importantly to treat various gastrointestinal disorders. Scientific studies carried out in the past two decades have validated many of the ethnomedicinal claims and researches have shown Triphala to possess free radical scavenging, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antimutagenic, wound healing, anticariogenic, antistress, adaptogenic, hypoglycaemic, anticancer, chemoprotective, radioprotective and chemopreventive effects. Clinical studies have also shown that Triphala was found to have good laxative property, to improve appetite and reduce gastric hyperacidity. Studies have also shown that Triphala was effective in preventing dental caries and that this effect was equal to that of chlorhexidine. The current review addresses the validated pharmacological properties of Triphala and also emphasizes on aspects that need further investigation for its future clinic application. KEYWORDS Ayurveda, Rasayana , Triphala, Terminalia chebula , Terminalia bellerica and Phyllanthus emblica and Emblica officinalis Figure 1. The Three Individual Components of Triphala Terminalia chebula Haritaki Emblica officinalis Phyllanthus emblica Amalaki Terminalia belerica Bibhitaki