How to Cite: Sayed, H. I. E., Aly, A. A., Mahmoud, A., & Arcipal, L. (2022). Knowledge and perception of nurses regarding fluid and electrolyte balance in intensive care units. International Journal of Health Sciences, 6(S3), 10894–10909. https://doi.org/10.53730/ijhs.v6nS3.8443 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 March 2022, Manuscript revised: 9 April 2022, Accepted for publication: 18 May 2022 10894 Knowledge and perception of nurses regarding fluid and electrolyte balance in intensive care units Hanaa Ibrahim El Sayed Associate Professor of Pediatric Nursing, Ibn Sina National College, Saudi Arabia Azza Anwar Aly* Associate Professor of Medical Surgical Nursing, Ibn Sina National College, Saudi Arabia Amira Mahmoud Lecturer of Nursing Management, Ibn Sina National College, Saudi Arabia Linie Arcipal* Clinical instructor of Obstetric Nursing, Ibn Sina National College, Saudi Arabia Abstract---Background: Fluid balancing activities must be accurately monitored as part of the patient's baseline information, which informs medical and nursing interventions to attain physiological stability. Therefore, the aim of this study was to explore nurses’ knowledge and perception of maintaining fluid and electrolyte balance. Methods: Descriptive design was used to conduct this study. Settings: This study was conducted at Maternity and Children Hospital, Makkah City, Saudi Arabia. Sample: A convenient sample of 66 nurses was represented in this study. The data were collected through a structured interview online questionnaire to assess nurses' knowledge and perception of maintaining fluid and electrolyte balance. Results: The findings revealed that all studied nurses were female (100%) and more than half of the studied sample was Saudi Arabian (56.1%). More than half of the studied sample had correct knowledge about the average urine output, the required amount of fluid intake per day, and normal measurement of CVP (60.6%, 59.1%, and 53.0% respectively). The majority of studied nurses reported that time management, workload, lack of skills, training, and lack of communication with other healthcare workers are affecting fluid balance monitoring. In conclusion: The findings of the study clearly revealed the need for a teaching program to enhance the knowledge and perception of maintaining fluid and electrolyte balance. Recommendation: Ongoing in-service education programs must be designed and implemented in