Available online at www.derpharmachemica.com Scholars Research Library Der Pharma Chemica, 2010, 2(3): 251-256 (http://derpharmachemica.com/archive.html) ISSN 0975-413X 251 www.scholarsresearchlibrary.com An efficient one-pot synthesis of 2, 4, 6-triaryl pyridines and their in vitro antimicrobial activity Bhaskar S. Dawane 1* , Shankaraiah G. Konda 1 and Raghunath B. Bhosale 2 Organic Research Laboratory, Department of Chemistry 1 Yeshwant Mahavidyalaya, Nanded-431602 (M.S) India 2 School of Chemical Sciences, Solapur University, Solapur ______________________________________________________________________________ Abstract A simple and efficient synthesis of 2,4,6-triaryl pyridines is described by the one-pot condensation of substituted acetophenones, 1-phenyl-3-(4’-hydroxy/chloro phenyl) pyrazol-4- carboxaldehyde, ammonium acetate and solid sodium hydroxide in polyethylene glycol (PEG- 400) as green reaction solvent. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity. Keywords: PEG-400, substituted acetophenones, 1-phenyl-3-(4’-hydroxy/chlorophenyl) pyrazol-4-carboxaldehyde, ammonium acetate, antimicrobial activity; ______________________________________________________________________________ INTRODUCTION Pyridine derivatives have occupied a unique position in medicinal chemistry. The naturally occurring B6-vitamins pyridoxine, pyridoxal, pyridoxamine and codecarboxylase contain a pyridine nucleus. Due to their Л-stacking ability, some pyridines are used in supramolecular chemistry. In addition, many pyridines are reported as antimalerial, anesthetic, anticonvulsant, antiepileptic, antioxidant, fungicidal, antibacterial, antiparasitic activities [1-4]. Pyridines with a 2,4,6-triaryl substitution pattern (Krohnke pyridines) [5] have been synthesized using various methods and procedures. Traditionally, these compounds have been prepared through the reaction of N-phenacylpyridinium salts with α, β-unsaturated ketones in the presence of NH 4 OAc [5-6]. However, the pyridinium salts and the unsaturated ketones have to be synthesized first, so this method is relatively expensive. Several improved methods and procedures have been developed for the synthesis of these pyridines such as solvent-free reaction