Accepted Manuscript Imbalance control in clinical trial subject randomization – from philosophy to strategy Wenle Zhao, Vance Berger PII: S0895-4356(18)30020-9 DOI: 10.1016/j.jclinepi.2018.02.022 Reference: JCE 9611 To appear in: Journal of Clinical Epidemiology Received Date: 9 January 2018 Revised Date: 20 February 2018 Accepted Date: 27 February 2018 Please cite this article as: Zhao W, Berger V, Imbalance control in clinical trial subject randomization – from philosophy to strategy, Journal of Clinical Epidemiology (2018), doi: 10.1016/j.jclinepi.2018.02.022. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.