Journal of Pharmaceutical Technology, Research and Management Vol. 1 May 2013 pp. 69–79 ©2013 by Chitkara University. All Rights Reserved. Synthesis and Pharmacological Evaluation of Some Novel Imidazole Derivatives for Their Potential Anti-Hypertensive Activity Anju Goyal Chitkara College of Pharmacy, Chitkara University, Punjab, INDIA Email: anju.goyal@chitkara.edu.in Jitender Singh Lord Shiva College of Pharmacy, Sirsa, Haryana, INDIA Dharam Pal Pathak Delhi Institute of Pharamceutical Sciences And Research, New Delhi, INDIA Abstract Benzimidazole, which is a heterocyclic nucleus, plays an important role in various medicines. A number of therapeutic agents such as H1 antihistaminic agent clemizole, a potent opioid analgesic etonitazene, nonnucleoside antiviral compound enviroxime, for promotion of excretion of uric acid irtemazole, non sedating antihistaminic agent astemizole, anti ulcer drugs omeprazole and pentoprazole, antihelmintic thiabendazole, antinematodal nocodazole etc. are based on benzimidazole heterocyclic nucleus. The synthesis of various benzimidazole derivatives by the reaction of ortho phenylene diamine I with various organic acids to yield 2-substituted benzimidazole derivatives II which on further treatment with nitric acid and sulphuric acid yielded 5-nitro-2- substituted benzimdazoles III. Coupling of this compound with halogenated beta picoline V yielded the title compounds. The structures of synthesized compounds were elucidated mainly by spectral evidence. All the compounds were screened for their anti-hypertensive activity. The compounds exhibited moderate to significant activities. Key Words: Synthesis, benzimidazoles, anti-inflammatory activity, anti-convulasant activity 1 INTRODUCTION C ardiovascular diseases are a cause of significant number of mortalities among deaths reported due to various diseases. One of the most common ailments of cardiovascular system is hypertension. A patient as per guidelines is said to be hypertensive when blood pressure measures of 140/90mmHg (systolic/diastolic pressure). Hypertension also involves slow