___________________________________________________________________________________________ *Corresponding author: Email: lparada@unsa.edu.ar; British Journal of Medicine & Medical Research 3(4): 1773-1785, 2013 SCIENCEDOMAIN international www.sciencedomain.org Genome-Wide Analysis of DNA Copy Number Changes in Liver Steatosis Félix Royo 1 , Amaia Zabala 2 , Nerea Paz 3 , Francesco Acquadro 4 , José J. Echevarria 5 , Iñaki Zabalza 6 , Juan C. Cigudosa 4 , José L. Zugaza 3,7 and Luis A. Parada 8* 1 CIC bioGUNE-CIBERehd, Par. Tec. Bizkaia, Derio, Spain. 2 CIC bioGUNE, Par. Tec. Bizkaia, Derio, Spain. 3 Department of Genetics, Physic Anthropology and Animal Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, 48940 Leioa, Spain. 4 Molecular Cytogenetics Group, Spanish Nacional Cancer Research Centre (CNIO), Madrid, Spain. 5 Department of Vascular and Interventional Radiology, Galdakao-Usansolo Hospital, Basque Country, Spain. 6 Department of Pathology, Galdakao-Usansolo Hospital, Basque Country, Spain. 7 Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park, Bg 205, Zamudio, Spain. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. 8 Institute of Experimental Pathology, Faculty of Health Sciences, National University of Salta, 4400-Salta, Argentina. Authors’ contributions This work was carried out in collaboration between all authors. Authors FR and LAP designed the study; authors FR, AZ and NP performed the analysis; authors FR, FA, JCC, JLZ and LAP did the statistic analysis; authors JJE and IZ performed the histological and immunohistochemical studies, author FR wrote the first draft, author LAP wrote the manuscript. All authors read and approved the final manuscript. Received 9 th November 2012 Accepted 28 th March 2013 Published 5 th June 2013 ABSTRACT Aims: Liver steatosis is the most common benign form of non-alcoholic fatty liver disease. It might be a risk factor for hepatocellular carcinoma, either (i) by causing fibrosis, which highly predisposes to hepatoma, or (ii) by being an early precursor of carcinoma, although it is usually considered not to be pre-neoplastic. We investigated Research Article