J. Biol. Sci. Med. (2017) 3 (2): 9-13 Journal of Biological Sciences and Medicine Available online at www.jbscim.com ISSN: 2455-5266 9 Research Article Open Access Anticarcinogenic effects of Soybean (Glycine max) in Mouse model System Udita Singh, Pallavi Indurkar, Arti Saxena, Jitendra Kumar Tripathi, Pranav Mishra, Narita Singh and Arvind Kumar Tripathi* Centre for Biotechnology Studies, A.P.S. University, Rewa, MP, India *Corresponding author: arvindt2584@gmail.com ARTICLE INFO ABSTRACT Article History: Received 2 June 2017 Accepted 23 June 2017 Available online 30 June 2017 Cancer is one of the rapidly growing diseases, which is now second leading cause of death. Our preexisted therapeutics has very little effect with higher range of side effects. Chemoprevention is a novel strategy which is currently based on the herbal drugs which have chemo-protective potentials. Our research work is based on the phytochemicals present in the plant which could reverse or suppress tumor growth. In present investigation we selected Glycine max (Soybean) to evaluate its anti-cancerous effects. We evaluated hepatic antioxidant profile and revealed that use of different doses of Glycine max work over GSH, Catalase activity meanwhile effect on lipid peroxidation reveal that lipid peroxidation was significantly decreased with higher doses of Glycine max. Our findings clearly suggest that Glycine max can significantly suppress or reverse tumor formation by increasing the activity of antioxidant enzymes and lipid peroxidation could be reversely altered. Key words: Chemoprevention; Glycine max; Antioxidant enzyme assay; Lipid Peroxidation Copyright: © 2017 Singh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction Our body is made up of billions of cells; many of these cells grow, divide, differentiate and then die in a predictable manner. Cancer occurs when something goes wrong with this system, causing uncontrolled cell division and growth. Chemoprevention is the use of pharmacologic or natural agents that inhibit the development of invasive cancer either by blocking the DNA damage that initiates carcinogenesis or by arresting or reversing the progression of premalignant cells in which such damage has already occurred. It is well established that primary prevention is the most effective means of disease control, especially for cancer remedy. It was defined as the utilization of chemically active compounds to reverse, suppress or prevent progression of disease from pre-invasive cancer to flank malignancy (Barnes 1995). The generation of reactive oxygen species (ROS) is a natural process in any biological system and their subsequent accumulation induces oxidative stress at the cellular level (Sultana and Saleem 2004). Although almost all organisms possess antioxidant defense and repair systems that have evolved to protect them against oxidative damage, these systems are insufficient to prevent the damage entirely. However, exogenous antioxidants, usually found in foods, can delay or inhibit the initiation or propagation