_____________________________________________________________________________________________________ *Corresponding author: E-mail: zohrabhatti@gmail.com, dramer2006@gmail.com; Journal of Pharmaceutical Research International 33(60B): 39-50, 2021; Article no.JPRI.78400 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Estimation of Knowledge, Attitude and Practices of Tuberculosis Patients in Penang: A Prospective Study Zohra Bhatti a* , Amer Hayat Khan a* , Syed Azhar Syed Sulaiman a , Madeeha Laghari a and Irfhan Ali Bin Hyder Ali b a Department of Clinical Pharmacy, School of Pharmaceutical Sciences Universiti Sains Malaysia, 11800 Penang, Malaysia. b Respiratory Department, Hospital Pulau Pinang, Penang, Malaysia. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i60B34584 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/78400 Received 14 October 2021 Accepted 19 December 2021 Published 21 December 2021 ABSTRACT Background: A clear understanding of knowledge, attitudes, and practices (KAP) of tuberculosis (TB) patients is important to encourage patients' contribution to TB prevention and control. Appropriate knowledge, positive attitude, preventing transmission and early diagnosis of TB are key factors in improving patient outcomes. Objective: This study aimed to investigate the knowledge, attitude, and practices about TB and determine related influencing factors among TB patients. Methodology: A cross-sectional prospective study by using a validated structured tool was conducted among TB patients more than 18 years of age. Descriptive statistics were used to summarize socio-demographic characteristics and TB knowledge, attitude, and practices level. To compare scores of each domain with various demographic factors, the Kruskal Wallis H test was applied. Results: Total participants in the study were 337. Of these, 231(68.5%) were male and 106(31.5%) were females with a mean age of 46.5±17.1 years. A significant difference was observed between males and females TB knowledge and practices concerning age. Patients with  12 years of educational background profoundly have better knowledge. Original Research Article