Int. J. Hyg. Environ. Health 204, 339 ± 346 (2002) ¹ Urban & Fischer Verlag http: // www.urbanfischer.de/journals/intjhyg International Journal of Hygiene and Environmental Health An interdisciplinary therapeutic approach for dealing with patients attributing chronic fatigue and functional memory disorders to environmental poisoning ± a pilot study Michael Lacour a , Thomas Zunder a , Markus Dettenkofer a , Sylvia Schˆnbeck a , Rainer L¸dtke b , Carl Scheidt c a Institute of Environmental Medicine and Hospital Epidemiology, Freiburg University Hospital, Germany b Karl and Veronica Carstens-Foundation, Essen, Germany c Department of Psychotherapy and Psychosomatic Medicine, Freiburg University Hospital, Freiburg, Germany Received: February 2, 2001¥Revision received: September 12, 2001¥Accepted: September 20, 2001 Abstract Nonspecific symptoms and a general feeling of ill health that is difficult to objectify are the commonest health problems with which patients present to an Environmental Medicine Outpatient Department (OPD). Of this group, a great proportion meets the classification criteriaforChronicFatigueSyndrome(CFS)orFunctionalMemoryDisordersinassociation with Idiopathic Chronic Fatigue (FMD-ICF). This is a longitudinal study of the OPD of EnvironmentalMedicine,FreiburgUniversityHospital,Germany,todeterminethefeasibility and impact of an interdisciplinary therapeutic approach (self-help program, acupuncture, psychosomaticsupportbygroupinterventions)in8patientswithCFS,FMD-ICF,orCFSin association with self-reported Multiple Chemical Sensitivities (sr-MCS). The intervention took into consideration the patients' need for treatment of physical aspects of their disease. This is an important step to motivate patients into required psychosomatic support. Althoughnoneofthepatientswaswillingtoacceptpsychosomaticsupportorpsychotherapy at study outset, acceptance of psychosomatic group interventions was high during the study course. Additionally five patients started with personal counseling at the Psychosomatic Clinic, and, without feeling stigmatized, 4 patients started with specific psychotherapy. The patients' quality of life showed no increase after four months, but, as shown by the Sum- Score of SF-36, it had improved significantly at the end of the study, which covered eight months' treatment (p  0.015). Two follow-up investigations showed that this improvement probably persisted in part (mainly in the dimensions mental health, social function, physical role function, and vitality). In conclusion our interdisciplinary therapeutic approach indicates successful treatment of patients attributing CFS, CFS/ sr-MCS, and FMD-ICF to environmental poisoning. We now plan to conduct a randomized controlled trial in the future. Key words: chronic fatigue syndrome ± CFS ± functional memory disorders ± multiple chemical sensitivity ± MCS 1438-4639/02/204-339 $15.00/0 Corresponding author: Dr.M. Lacour, Institute of Environmental Medicine and Hospital Epidemiology, Freiburg UniversityHospital,HugstetterStra˚e55,D-79106Freiburg,Phone:  497612705484,Fax:  497612705440,E- mail: mlac@iuk3.ukl.uni-freiburg.de