Accepted Manuscript Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy Shen-Zhen Ren, Zhong-Chang Wang, Dan Zhu, Xiao-Hua Zhu, Fa-Qian Shen, Song- Yu Wu, Jin-Jin Chen, Chen Xu, Hai-Liang Zhu PII: S0223-5234(18)30718-9 DOI: 10.1016/j.ejmech.2018.08.048 Reference: EJMECH 10659 To appear in: European Journal of Medicinal Chemistry Received Date: 24 April 2018 Revised Date: 20 July 2018 Accepted Date: 17 August 2018 Please cite this article as: S.-Z. Ren, Z.-C. Wang, D. Zhu, X.-H. Zhu, F.-Q. Shen, S.-Y. Wu, J.-J. Chen, C. Xu, H.-L. Zhu, Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy, European Journal of Medicinal Chemistry (2018), doi: 10.1016/j.ejmech.2018.08.048. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.