How to Cite: Thimmaraju, M. K., Boddeda, B., Arjun, G., Garige, A. K., Chandupatla, V., Kumar, K. R., & Billah, A. M. (2022). Design and invitro evaluation of gastro retentive oral matrix tablet formulations of ketorolac tromethamine. International Journal of Health Sciences, 6(S2), 1945–1952. https://doi.org/10.53730/ijhs.v6nS2.5178 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Corresponding author: Thimmaraju, M. K.; Email: manishcancer@gmail.com Manuscript submitted: 27 Jan 2022, Manuscript revised: 18 Feb 2022, Accepted for publication: 09 March 2022 1945 Design and invitro evaluation of gastro retentive oral matrix tablet formulations of ketorolac tromethamine Manish Kumar Thimmaraju Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal, Telangana, India Email: manishcancer@gmail.com Bhavani Boddeda Koringa College of Pharmacy, Korangi, East Godavari Andhra Pradesh India Goje Arjun Teegala Ram Reddy College of Pharmacy, Hyderabad, Telangana, India Anil Kumar Garige Jayamukhi Institute of Pharmaceutical sciences, Narsampet, Warangal, India Vijitha Chandupatla Vaagdevi Institute of Pharmaceutical sciences, Bollikunta, Warangal Telangana India Konda Ravi Kumar Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, India A. Mohathasim Billah MRM College of Pharmacy, Hyderabad, Telangana, India Abstract---Ketorolac Tromethamine floating tablets were prepared by using combination of hydrophilic polymers such as Hydroxy Propyl Methyl Cellulose 4000 cps grade and 100000 cps grade. Eight set of formulations were prepared by gradual increasing and decreasing concentrations of above two polymers. The floating pattern was found to be instant for all the formulations and best controlled release profile was achieved for few set of formulations. The drug content, tablet weight, friability and weight variation were found to be within the limits. Validated UV spectrophotometric method was developed and standard linear regression was used to determine the concentration of