Blocking the Rac1-TRPC5 pathway protects human podocytes Yiming Zhou 1,5,6,7# , Choah Kim 2,7 , Juan Lorenzo B. Pablo 2,7 , Fan Zhang 1 , Ji Yong Jung 1,3 , Li Xiao 1 , Silvana Bazua 1,2 , Maheswarareddy Emani 2 , Corey Hopkins 4 , Astrid Weins 5 , Anna Greka 1,2# 1. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA 2. Broad Institute of MIT and Harvard, Cambridge, MA, USA 3. Department of Internal Medicine, Gachon University Gil Medical Center, College of Medicine, Incheon, Republic of Korea 4. Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA 5. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 6. Current address: Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China 7. These authors contributed equally # Corresponding author . CC-BY-NC-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted January 21, 2021. ; https://doi.org/10.1101/2020.08.28.272344 doi: bioRxiv preprint