Kasturi et al Journal of Drug Delivery & Therapeutics. 2017; 7(7):46-49 ISSN: 2250-1177 [46] CODEN (USA): JDDTAO Available online on 25.12.2017 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-17, publisher and licensee JDDT, This is an Open Access article which permits unrestricted non- commercial use, provided the original work is properly cited Open Access Research Article LIQUISOLID TECHNIQUE AS A PROMISING TOOL TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUG VALSARTAN Madhavi Kasturi, Neelesh Malviya Research Scholar, Department of Pharmaceutics, Smriti College of Pharmaceutical Education, Indore– 452010 E-mail address: madhavi2386@gmail.com ABSTRACT “Liquisolid Technique” considered as new technique to enhance solubility and dissolution rate of poorly water soluble drugs. These formulations are prepared by mixing drug in liquid state (solution, suspension or emulsion using non-volatile solvent) with carrier and coating material to form dry, free-flowing, readily compressible powder. In the current research work liquisolid technique is employed to enhance solubility and dissolution of antihypertensive drug Valsartan, which is poorly water soluble (0.021mg/ml) possessing very low bioavailability of 23%. Liquisolid formulation VLS9, containing Tween 80 (non-volatile solvent), Avicel PH102 (carrier) and Aerosil 200 (coating material) showed better flow properties and high in-vitro dissolution profile. Cite this article as: Padiyar Kasturi M, Malviya N, Liquisolid technique as a promising tool to enhance solubility and dissolution of poorly water soluble drug valsartan, Journal of Drug Delivery and Therapeutics. 2017; 7(7):46-50 INTRODUCTION: Solubility is one of the key parameters to achieve desired concentration of drug in systemic circulation for showing affective pharmacological response. Low aqueous solubility is the major problem with formulation development of new chemical entities. Solubility enhances dissolution which in turn may increase bioavailability of poorly water soluble drugs. “Liquisolid Technique” also known as “Powder Solution Technology” is considered new, safe and economic technique to enhance solubility and dissolution profile of poorly water soluble drugs. Liquisolid formulations are prepared by converting liquid drug or drug in liquid state (solution, suspension or emulsion using non-volatile solvent) into dry, non- adherent, free-flowing, readily compressible powder by blending liquid medication with carrier and coating materials. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in increased dissolution rate and bio availability 1 . Valsartan is an angiotensin II receptor antagonist used in the management of hypertension 2 . Valsartan is an antihypertensive drug having low aqueous solubility of 0.021mg/ml and low bioavailability of 23%. The aim of current research work was to enhance solubility and dissolution of poorly water soluble drug. MATERIALS AND METHODS: Valsartan was gift sample received from Hetero Drugs, Hyderabad. Other excipients include Avicel PH 102, Aerosil 200, Propylene glycol (PG), polyethylene glycol 600 (PEG600), Tween 80. All reagents used were of analytical grade. Methods Saturation solubility studies Saturation solubility studies of Valsartan were carried out in distilled water, propylene glycol, PEG 600 and Tween 80. Saturated solutions prepared in above vehicles were kept in an orbital shaker (Remi motors Pvt. Ltd Mumbai, India.) for 48 h at 25 °C. The solutions were then filtered and drug content was determined using UV- VIS spectrophotometry (Shimadzu 1800, Japan) at 250 nm. . From these results, the solubility of valsartan in the respective liquid vehicle was calculated. Each experiment was carried out in triplicate 3 . Preparation of liquisolid formulations This drug solution or suspension is incorporated into specific quantity of carrier material which should possess sufficient absorption properties. The resulting wet mixture is then converted into a dry–looking, non adherent, free-flowing and readily compressible powder by the simple addition and mixing of a calculated