Original article [1] Improved circulating tumor cell detection by a combined EpCAM and MCAM CellSearch enrichment approach in breast cancer patients undergoing neoadjuvant chemotherapy Wendy Onstenk 1 , Jaco Kraan 1 , Bianca Mostert 1 , Mieke M. Timmermans 1 , Ayoub Charehbili 2,3 , Vincent T.H.B.M. Smit 4 , Judith R. Kroep 2 , Johan W.R. Nortier 2 , Saskia van de Ven 2 , Joan B. Heijns 5 , Lonneke W. Kessels 6 , Hanneke W.M. van Laarhoven 7 , Monique M.E.M. Bos 8 , Cornelis J.H. van de Velde 3 , Jan W. Gratama 1 , Anieta M. Sieuwerts 1 , John W.M. Martens 1 , John A. Foekens 1 , Stefan Sleijfer 1 1 Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands 2 Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands 3 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands 4 Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands 5 Department of Medical Oncology, Amphia Hospital, Breda, The Netherlands 6 Department of Internal Medicine, Deventer Hospital, Deventer, The Netherlands 7 Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam 8 Department of Internal Medicine, Reinier de Graaf Hospital, Delft, The Netherlands Running title Improved CTC detection using EpCAM and MCAM in breast cancer Corresponding author Wendy Onstenk Erasmus MC Cancer Institute, Department of Medical Oncology and Cancer Genomics Netherlands Erasmus University Medical Center Wytemaweg 80 3015 CN, Rotterdam, The Netherlands T: 0031 10 704 13 24 F: 0031 10 704 10 05 E: w.onstenk@erasmusmc.nl on January 21, 2022. © 2014 American Association for Cancer Research. mct.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on December 31, 2014; DOI: 10.1158/1535-7163.MCT-14-0653