www.electrophoresis-journal.com Page 1 Electrophoresis Received: 10 01, 2018; Revised: 12 24, 2018; Accepted: 01 13, 2019 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/elps.201800414 . This article is protected by copyright. All rights reserved. The self-disproportionation of enantiomers (SDE): the effect of scaling down, potential problems vs. prospective applications, possible new occurrences, and unrealized opportunities? Jianlin Han 1 Alicja Wzorek 2,3 Vadim A. Soloshonok 3,4 * Karel D. Klika 5 * 1 College of Chemical Engineering, Nanjing Forestry University, 210037 Nanjing, P. R. China. ORCID: https://orcid.org/0000-0002-3817-0764. Email address: hanjl@njfu.edu.cn 2 Institute of Chemistry, Jan Kochanowski University in Kielce, Świętokrzyska 15G, 25-406 Kielce, Poland. ORCID: https://orcid.org/0000-0001-9041-7034. E-mail address: alicja.wzorek@ujk.edu.pl 3 Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain. ORCID: https://orcid.org/0000-0003-0681-4526. E-mail address: vadym.soloshonok@ehu.es 4 IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain. 5 Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. ORCID: https://orcid.org/0000-0001-7009-1487. E-mail address: k.klika@dkfz.de Correspondence: Professor Vadim A. Soloshonok, Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain. ORCID: https://orcid.org/0000-0003-0681-4526. Email: vadym.soloshonok@ehu.eus; Tel: +34 943015177; Fax: +34 943015270. Dr. Karel D. Klika, Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. ORCID: https://orcid.org/0000-0001-7009- 1487. Email: k.klika@dkfz.de